Example sentences for: differentiate

How can you use “differentiate” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Meltrin α is expressed in vivo during development in condensed mesenchymal cells that give rise to skeletal muscle while meltrin β is expressed in craniofacial and dorsal root ganglia where neuronal lineages differentiate [ 26].

  • Pundits debated whether his platform would: 1) differentiate him from Bush; or 2) alienate him from the Republican establishment.

  • Heart and skeletal muscle share many key gene regulatory factors and downstream genetic programs, and the loss of a few key negative regulatory checkpoints might allow the cells to differentiate towards a cardiac phenotype.

  • Tat has been shown to down-regulate mannose receptor, EDF-1, CD3-gamma, and TCR/CD3 surface receptor [ 14 ] . Tat reduces mannose receptor levels and promoter activity in mature macrophages and dendritic cells by interfering with the host transcriptional machinery; resulting in decreased levels of surface mannose receptor needed for Ag (mannosylated albumin uptake) or pathogen capture (Pneumocystis carinii phagocytosis), and eventual delivery to MHC class II-containing intracellular compartments [ 15 ] . EDF-1, a gene down-regulated when endothelial cells are induced to differentiate in vitro , was shown to be down-regulated by Tat at the transcriptional level, resulting in the inhibition of endothelial cell growth and in the transition from a nonpolar cobblestone phenotype to a polar fibroblast-like phenotype [ 16 ] .

  • They do not take family history of premature coronary artery disease into account; they do not benefit from new assays that can differentiate lipoproteins by particle size and number, both of which are important factors in atherogenicity; and they do not include the quality of the patient's diet, abdominal fat content, racial and ethnic genetic differences, confounding medical conditions, certain gender differences, and other factors.


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