Example sentences for: cytosol

How can you use “cytosol” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The soluble messenger IP 3 binds to receptors located on calcium store membranes, causing release of calcium into the cytosol, while DAG remains in the membrane, where it can activate downstream effectors.

  • A portion of the cellular eIF4E is imported into the nucleus through a mechanism that requires the protein 4E-T [ 31 ] . In the nucleus eIF4E is localized to specific nuclear bodies and associates with promyelocytic leukemia protein (PML, [ 32 ] ). Nuclear eIF4E appears to be involved in export of cyclin D1 mRNA to the cytosol [ 25 ] . Both 4E-T and PML interact with the same domain of eIF4E that binds 4EBP [ 32 ] . Thus expression of constitutively active 4EBP may block nuclear functions of eIF4E, one consequence being a reduction in cyclin D1 mRNA that can be translated in the cytoplasm.

  • In plant cells V-ATPases are responsible for the deacidification of the cytosol and the energization of secondary transport processes across the tonoplast, as well as in the endocytotic and secretory pathways [ 12 ] . In addition, the vacuolar type ATPase is thought to be primarily responsible for the acidification and expansion of the large central vacuole [ 12 13 14 15 ] . In plants a critical event in growth and development is the maturation and expansion of the central vacuole.

  • The homogenate was centrifuged at 100,000 × g for 30 minutes at 4°C and the supernatant fraction (cytosol) was collected.

  • Interestingly, ThDP-utilizing enzymes in mitochondria are much less affected (as revealed by loss of activity) upon progressive depletion of thiamine available to TRMA cells than are ThDP-utilizing enzymes of the cytosol [ 6 ] . For these reasons, we have examined the uptake of thiamine and especially ThDP by mitochondria from several human cell types, including cells from TRMA patients.


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