Example sentences for: cytotoxic

How can you use “cytotoxic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Intracellular bile acid binding proteins have been postulated to participate in the transcellular transport as well as to buffer against the cytotoxic effects of bile acids.

  • One drug identified in this screen, flavopiridol, was found to be significantly cytotoxic for cell lines derived from activated B-like DLBCL.

  • Cell-mediated immunity and direct killing by cytotoxic lymphocytes from the vagina and colon lamina propria may be an important factor in containing viral infection at the site of primary infection [ 18] [ 19, 20].

  • This is especially relevant to the design of subunit vaccines for malaria and schistosomiasis where high titers of high affinity antibodies are usually the best defence against invading organisms [ 11 16 24 ] . Creating T cell epitopes in expressed proteins has been demonstrated here for Hartley strain guinea pigs, and for various inbred strains of mice [ 37 38 ] . Interestingly, the introduction of T cell epitopes from a hen-egg lysozyme or ovalbumin into mouse TNF-alpha also resulted in an increased cross-reactive antibody response in mice [ 38 ] . However, the protein construct was no longer cytotoxic for L929 cells, suggesting that the modified protein was not in the correct tertiary configuration.

  • Limitations in previous studies of in vivo adenoviral transduction have been the poor stability of adenoviral transduction in dividing cells and the induction of cytotoxic immune responses to adenoviral gene products.


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