Words similar to cytotoxic
Example sentences for: cytotoxic
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HGEN, HGEC and HPT were chosen for examination in this study because these cell types, at least in vitro , have been shown to be injured by Stx-1 [ 6 7 8 ] . Mesangial cells were not examined since Stx-1 has not been demonstrated to affect their viability [ 13 ] . Previous studies have separately examined the cytotoxic effect of Stx-1 on HGEN [ 8 ] , HGEC [ 10 ] , and HPT [ 9 ] , however this is the first study to directly compare Stx-1 sensitivity of these renal cell types.
Based on histologic evidence, glomerular endothelial cells have been invoked as being primarily involved in HUS renal injury [ 7 ] . In vitro studies have demonstrated that human glomerular endothelial cells (HGEN) bind Stx-1 and are modestly sensitive to the toxin's cytotoxic effect [ 8 ] . Recent work indicates that other renal cell types may be Stx targets in HUS: cultured human proximal tubule (HPT) [ 9 ] and human visceral glomerular epithelial (HGEC) [ 10 ] cells express abundant amounts of Gb3 and are highly sensitive to the cytotoxic effect of Stx-1.
As shown in Table 3, the combination of PMA (50 ng/ml) and CEES (500 μM) was more cytotoxic (after 24 hours) toward the RAW264.
No cytotoxic or apoptosis-inducing activity was associated with this growth inhibition ( [ 46 ] , and data not shown).
The majority of patients (69%) had secondary AML transformed from either MDS (n = 10), CML (n = 5) or other myeloproliferative diseases (n = 4), or secondary to cytotoxic agents (n = 1).