Words similar to cytotoxic
Example sentences for: cytotoxic
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However IL-12 by itself at concentrations of 25 U or 125 U/10 6cells is unable to cause neither an increase in the NK phenotype nor in their cytotoxic ability (Figure 6& 7).
Depending on the experimental conditions, treatment of RPE with H 2 O 2 can cause an alteration of cellular functions [ 6 7 ] or cell death [ 8 9 ] . Cytotoxic levels of H 2 O 2 can cause significant mitochondrial [ 10 ] and genomic [ 11 ] DNA damage in RPE simulating the features of programmed cell death [ 8 12 ] . Studies from other cell types indicate that early cellular events following H 2 O 2 treatment include morphological alterations and actin re-organization [ 13 ] . In addition, activation of the ERK (p42/44, Extracellular signal-Regulated Kinase) MAP kinases (Mitogen-Activated Protein kinases) can occur within minutes following cellular oxidative stress.
To analyze morphological changes of RPE cells treated with a cytotoxic concentration of H 2 O 2 , ARPE-19 cells were treated with 1.5 mM H 2 O 2 for various periods of time and then processed for actin staining.
AICD = activation-induced cell death; CTLA = cytotoxic T-lymphocyte antigen; ELISA = enzyme-linked immunosorbent assay; FITC = fluorescein isothiocyanate; IL = interleukin; PE = R-phycoerythrin; PG = proteoglycan; PGIA, proteoglycan-induced arthritis; SCID = severe combined immunodeficient; TCR = T-cell receptor; TGF = transforming growth factor; WT = wild-type.
The following primary monoclonal antibodies were purchased from DAKO Corporation, Carpinteria, CA: CD1a Langerhans' cell (clone NA1/34), CD3 T cell (PC3/188A), CD8 suppressor /cytotoxic T cell (DK25), CD14 Monocyte (TUK4), CD68 Macrophage (KP1), HLA-ABC Antigen/ MHC class I (W6/32), IgG (A57H), IgM (R1/69), and Ki67 Proliferating cells (Ki67).
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