Words similar to cytotoxic
Example sentences for: cytotoxic
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Testicular hyaluronidase PH-20 counteracts TGF-β1-induced TNF-resistance in L929 cells [ 8 ] . The goal of the present study was to examine whether lysosomal Hyal-1 and Hyal-2 enhance TNF cytotoxic function and counteract TGF-β1-mediated TNF-resistance in L929 cells.
24 cells after treatment with glycine- and taurine-conjugated bile acids were compared to assess the cytotoxic potential of bile acids on these cells.
LPS is a major component of the cell wall of gram-negative bacteria and is known to trigger a variety of inflammatory reactions in macrophages and other cells having CD14 receptors [ 7 8 ] . In particular, LPS is known to stimulate the macrophage secretion of nitric oxide [ 9 ] and inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1-beta) [ 10 ] . For this reason, we also determined if TNF-alpha or IL-1-beta were capable of enhancing the cytotoxic effects of CEES.
IL-12 may thus be a candidate to control the cytolytic arm of initial immune response to pathogens by inducing expansion of cytotoxic T cell only when antigen is encountered [ 29 ] . The biologic significance of the multiplicity of cytokines which can stimulate the proliferation of T and NK cells is unclear.
Following low dose IL-2 treatment in leprosy patients, NK cell numbers were found to increase 6-fold and IL-2 therapy of HIV patients resulted in enhanced NK and LAK cell activity in vitro [ 18 ] IL-2 subcutaneously given resulted in, in vivo expansion of CD16 positive NK cells to very large numbers which showed LAK activity and ADCC (Antibody Dependent Cellular Cytotoxicity) in vitro [ 19 ] . In view of the above mentioned and other reports available in literature, a pilot study was undertaken to see the effect of IL-2 and/or IL-12 stimulation on a long term basis and study the phenotypic changes corresponding to the cytotoxic changes after in vitro culture of the peripheral blood lymphocytes.
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