Words similar to cytosolic
Example sentences for: cytosolic
How can you use “cytosolic” in a sentence? Here are some example sentences to help you improve your vocabulary:
This final phase in the cell death cascade can be monitored experimentally by measuring the release of the ubiquitous cytosolic enzyme, LDH.
The activity of the catalytic subunit of PP1 is controlled by its interaction with a large number of regulatory subunits, many of which also target it to specific subcellular compartments [ 7 24 33 ] . The major ones include the glycogen-targeting subunits (G M , G L ) [ 34 ] , myofibrillar-targeting subunit (M 110 ) [ 34 ] , nuclear inhibitor of PP1 (NIPP-1) [ 35 ] , PP1 nuclear targeting subunit (PNUTS) [ 36 37 ] , mitosis-regulating subunit Sds22 [ 38 39 40 ] , ribosomal protein L5 [ 41 ] and small cytosolic inhibitory proteins, I-1, I-2, and DARRP-32 (Dopamine and cAMP-regulated phosphoprotein, Mr 32,000) [ 7 23 25 ] . The physiological role of many of these interactions has been revealed in recent studies.
Although the estimated concentration, in mice and human cells, of intracellular ThDP is about 30 μM, much of this is found in a low turnover pool representing enzyme-bound ThDP [ 4 17 ] . The estimated concentration of free cytosolic ThDP available for intracellular transport is about 10% of the total concentration and thus 2 to 3 μM [ 4 17 18 ] . Hence the physiological significance of the mitochondrial ThDP uptake just decribed is uncertain.
The dihydropyridine receptor (DHPR) of skeletal muscle consists of α 1S , α 2 , β 1a and γ 1 subunits [ 1 ] . The α 1 subunit is a large four-repeat transmembrane protein of ~220 KDa that contains the basic functional elements of the L-type Ca 2+channel, including the Ca 2+selective pore and S4 "voltage-sensing" transmembrane segments in each of the four internal repeats [ 2 ] . β subunits are ~65 kDa cytosolic proteins essential for membrane trafficking, modulation of channel kinetics, and for excitation-contraction (EC) coupling [ 3 4 ] . The α 2 subunit is a highly glycosylated ~175 kDa protein formed by two disulfide-linked peptides [ 5 ] , whereas the γ 1 subunit is a ~32 kDa skeletal muscle-specific protein of four presumptive transmembrane domains with almost unknown function [ 6 7 ] .
Measurement of the apparent cytosolic free Ca 2+concentration
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