Words similar to cytoskeletal
Example sentences for: cytoskeletal
How can you use “cytoskeletal” in a sentence? Here are some example sentences to help you improve your vocabulary:
Interestingly, inhibition of Rho-p160ROCK has recently been shown to give similar lymphocyte morphology as inhibition of Rho with C3 [ 50 ] . Another interesting candidate may be p120 PKN, as recent studies have established that PKN phosphorylates cytoskeletal intermediate filaments [ 47 ] and is directly linked to the cytoskeletal network through associations with α-actinin [ 48 ] . Also, PKN may be involved in relating cytoplasmic signals to the nucleus, for in response to stress, nuclear translocation of PKN occurs [ 49 ] . This is particularly important in light of previous work demonstrating that inactivation of Rho in peripheral blood T lymphocytes inhibits costimulatory signals up-regulating IL-2 production [ 25 ] . Future experiments will focus on determining the relationship of Rho GTPases and the regulation of T cell morphology [ 25 51 52 ] .
It should be noted that besides profilin, there are many other cellular proteins known to modulate actin filamentation and cytoskeletal dynamics, and profilin itself binds to a large number proteins, many with poly-proline sequences [ 42 43 ] . Clearly, identification of the various members of the cytoskeletal signaling pathway will constitute an important step in understanding host-RSV interaction, and may lead to additional targets for pathological intervention.
This model is consistent with the recent report that MHCK-A displays enrichment into anterior F-actin-rich protrusions of polarized cells during chemotaxis, and into phagocytic and macropinocytotic extensions [ 23 ] . The polar localization of MHCK-A would be consistent with the long-standing "polar relaxation" model for cytoskeletal reorganization during cytokinesis [ 33 ] . MHCK-A may represent a factor that contributes to polar relaxation in this system via polar disassembly of myosin II filaments.
While this issue needs further work, it is clear that detergent extraction alone cannot be used as the sole criterion for cytoskeletal association of proteins such as moesin as stated frequently in the recent literature.
By combining traditional biochemical subcellular fractionation methods with massively-parallel gene profiling technology, we were able to ask the question: how many different eukaryotic mRNAs interact with the cytoskeletal network and what is their identity?
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