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Example sentences for: cc

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cc: Mr. Thomas E. Kelly Director, Office of Regulatory
Microsatellite instability (MSI) is hallmark of mismatch repair-deficient cancers, which has been observed in all cancers arising from Hereditary Non-polyposis Colorectal Cancer (HNPCC) syndrome, some sporadic colorectal and other cancers [ 38 ] . MSI is generally associated with germ-line mutations in one of two MMR genes, hMLH1 and hMSH2 . Epigenetic inactivation of promoter hypermethylation of APC and HIC1 also results in MSI phenotype in sporadic colorectal cancers [ 39 40 ] . Accumulating evidence supports the view that promoter methylation of mismatch repair genes may be related to MSI phenotype [ 41 42 ] . A number of previous studies have shown the existence of MSI phenotype in CC [ 43 44 ] . In the present study, we found that MSI-H occurs at an increased frequency in tumors with HIC1 and APC promoter hypermethylation.
The compounds tested generally inhibited CV-1 cell growth at high concentrations, and 3H-thymidine uptake in HeLa cells by 50% only at concentrations above 20 μg/mL except for Co(III)TPP(2,6-F2)S (CC 50 < 5 μg/mL).
cc: Mr. Andrew S. Fishel Managing Director Federal Communications Commission
Fitch and colleagues [ 32 ] also determined that the feminization (reduction in size as compared to the CC of male rats) of the female CC only occurs if the ovaries are intact and the CC is exposed to estrogen.