Words similar to cc-
Example sentences for: cc-
How can you use “cc-” in a sentence? Here are some example sentences to help you improve your vocabulary:
Because of the high catalytic efficiency and broad substrate specificity, β-lactamases have been extensively used in the ADEPT approach to activate prodrugs of vinca alkaloids [ 27 ] , nitrogen mustard [ 28 29 30 31 32 ] , doxorubicin [ 33 34 35 36 ] and others [ 37 ] . To take advantage of the potent antitumor activity of the CC-1065 class of compounds and the ADEPT approach, we have synthesized β-lactam prodrugs.
This is the first report demonstrating synthesis of a prodrug comprised of a cephalosporin and a CC-1065 analogue.
CC-1065 (Figure 1) is among the most potent antitumor agents discovered [ 9 10 11 12 13 ] . It binds to double-stranded B-DNA within the minor groove with a sequence preference for 5'-d(A/GNTTA)-3' and 5'-d(AAAAA)-3', and alkylates the N3 position of the 3'-adenine with its left-hand CPI segment [ 14 15 ] . CC-1065 also inhibits gene transcription by interfering with binding of the TATA box-binding protein to its target DNA [ 16 ] . Despite its high potency and broad spectrum of antitumor activity, CC-1065 cannot be used in humans because it causes delayed death in experimental animals [ 17 ] . To pursue compounds possessing the potent antitumor activity but devoid of the toxic side effects of the parent compound, many CC-1065 analogues have been synthesized [ 18 19 20 21 22 23 24 25 26 ] .
For your convenience, a copy of Form CC-40 (which should be filed with your Indiana State Income Tax) is enclosed.
As observed for other compounds of the CC-1065 class [ 25 37 38 ] , both prodrug 2 and the free drug 1 caused DNA fragmentation, and the cells died by apoptosis (data not shown).
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