Words similar to ccr
Example sentences for: ccr
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Cellulose acetate phthalate (CAP) is a promising microbicide candidate for prevention of infection by sexually transmitted disease (STD) pathogens, including HIV-1 [ 1 2 3 4 5 6 7 ] . CAP inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gp120, while leaving the site for the primary cellular receptor CD4 accessible [ 8 9 ] Soluble CD4 (sCD4) was shown to inhibit HIV-1 infection by two mechanisms: reversible blockage of virus binding to receptors, and irreversible inactivation of virus infectivity [ 10 ] . Since CAP and sCD4 bind to distinct domains on the HIV-1 envelope, it was of interest to determine whether or not these two ligands affect virus infectivity synergistically as do other combinations of anti-HIV-1 drugs and sCD4 [ 11 12 ] Binding of sCD4 leads to conformational changes in gp120 [ 13 14 15 16 17 ] . Binding of gp120 to coreceptors CXCR4 and CCR5, respectively, triggers additional conformational changes in HIV-1 envelope glycoproteins [ 18 19 ] For these reasons it was of interest to determine whether a) pretreatment of HIV-1 with sCD4 would affect subsequent binding of CAP to virus particles, and b) CAP binding to virus particles in the presence or absence of sCD4 would elicit conformational changes which could affect HIV-1 infectivity.
Members of the DNase 1, LINE-1 repeats, inositol 5'-polyphosphate phosphatase, Nocturnin, CCR4, cytolethal distending toxin, neutral sphingomyelin phosphodiesterase, and amino acid methyltransferase families were found with expectation values of 10 -4or less to be significantly similar to APE1.
MCP-1 has been shown to play an important role in the development of arthritis in MRL-lpr mice [ 22], whereas the migration of monocytes into inflammatory sites was reduced in the CCR2-deficient mouse [ 23].
5%–30%) of CCR4, CXCR3, and CCR5 on peripheral blood lymphocytes isolated from the same participants, and this variation did not correlate with the presence of disease in either group (data not shown).
Moreover, CCR5 expression did not correlate with expression of LT-α by RA synovial CD4 +memory T cells.
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