Words similar to adenylyl
Example sentences for: adenylyl
How can you use “adenylyl” in a sentence? Here are some example sentences to help you improve your vocabulary:
Experimental analysis on the Methanococcus CyaB homolog revealed no adenylyl cyclase activity comparable to that seen in Aeromonas CyaB [ 16 ] . Likewise, there is no evidence for a widespread presence of the ThTPase activity in the organisms that contain CYTH domain proteins [ 17 ] . Hence, the principal biological function of the CYTH domains may be different from those of the experimentally characterized members of this family.
Based on these two sets of results, if the analgesic effect of butorphanol is mediated via μ opioid receptors through the inhibitory effect of these receptors on adenylyl cyclase, the equal efficacy of morphine and butorphanol would support an equal antinociceptive effect of these two drugs.
Classic adenylyl and guanylyl cyclases show a far more sporadic distribution, and are often present in multiple copies fused to a variety of signaling domains such as the cyclic nucleotide binding domains [ 24 ] . Cyclic nucleotide generating activity is not known to exist in a subset of the archaea [ 25 ] , though most of them contain a well-conserved copy of the CYTH domain.
We have shown that δ-opioids increase the phosphorylation of ERKl/2 in HEK-293 cells when the mouse wild type (WT) δ-OR is stably expressed [ 11 13 ] . The concentrations required to observe DSLET-mediated ERK phosphorylation (EC 50 = 10 nM; Figure 1a) are consistent with those reported for other δ-OR-mediated events, including G protein activation and adenylyl cyclase inhibition [ 16 17 ] . Moreover, no change in total ERK expression was observed, concomitantly, with ERK phosphorylation in any of our experiments (data not shown).
This compound selectively inhibits mammalian PLC, but has no direct effect on bacterial PLC, bacterial or mammalian phospholipase A 2 or adenylyl cyclase [ 14 ] . U73343, a structural analogue of U73122 that differs by only one double bond, has no direct effect on PLC and is commonly used as a negative control.
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