Example sentences for: adenylyl

How can you use “adenylyl” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In heterologous expression systems, the 5-HT 2C receptor can couple to two different K +channels [ 26 ] and in some cases either activation or inactivation of adenylyl cyclase has been demonstrated in addition to the well-known activation of phospholipase C and PI turnover.

  • Based on these two sets of results, if the analgesic effect of butorphanol is mediated via μ opioid receptors through the inhibitory effect of these receptors on adenylyl cyclase, the equal efficacy of morphine and butorphanol would support an equal antinociceptive effect of these two drugs.

  • However, the CyaB adenylyl cyclase, which was identified in the bacterium Aeromonas hydrophila is unrelated to any of these above superfamilies of enzymes [ 16 ] . Though close relatives of this enzyme exist in some bacteria, like

  • Intracellular signaling machinery of adenylyl cyclase is required for cytoskeletal organization, vessel maturation, and vessel integrity [ 24 ] . PF4 is a chemokine that binds to FGF and is a known inhibitor of EC proliferation and migration [ 25 ] . Thus, the upregulation of PF4 might limit the degree of activation of ECs and morphogenic differentiation.

  • Organic phosphate compounds are the central metabolites of all biological systems [ 1 2 ] . Some are the basic building blocks of nucleic acids, some like ATP and GTP, are additionally, cellular energy stores, others like cAMP or cGMP are messengers in signal transduction, and, yet others, such as FAD, NAD, thiamine phosphates and pyridoxal phosphate are cofactors for a range of enzymes [ 1 2 ] . Protein domains belonging to a relatively small set of structural folds are known to bind or catalyze reactions that utilize these organic phosphate compounds (see SCOP database: http://scop.mrc-lmb.cam.ac.uk/scop/) [ 3 4 ] . Several of these folds trace back to some of the earliest phases of the evolution of the protein world, and participate in a wide range of disparate biological functions in extant proteins [ 4 5 ] . Some folds, such as the P-loop fold, the Rossmann fold and the Hsp70-like fold, have been well studied, and comprise mainly of dedicated nucleotide binding or hydrolyzing proteins [ 6 7 8 9 ] . Others, such as the palm-domain, which is found in adenylyl cyclases and various nucleic acid polymerases, belong to more generalized protein folds that contain representatives with diverse biochemical activities [ 4 10 11 ] . Current availability of extensive genome sequence data, allows one to identify less numerous, nevertheless biological important organic phosphate-binding domains that may have previous eluded detection.


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