Example sentences for: adenylate

How can you use “adenylate” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • 3shows that the signal, which regulates the expression of human CD8, is cAMP-mediated, since direct activation of adenylate cyclase by cholera toxin produced the same effects as the di-butiryl cAMP analog.

  • Furthermore, subclinical cerebral damage, increased adenylate cyclase in the central nervous system, and nutritional status identified by albumin level are predisposing factors for postoperative delirium [ 1].

  • cAMP is an important signaling molecule that can be found in specific cellular domains [ 53 ] . Levels are controlled through synthesis via adenylate cyclase, and degradation via phosphodiesterases (PDEs).

  • For many labile mRNAs, adenylate uridylate-rich elements (AREs) are required for their rapid degradation.

  • Metabotropic glutamate receptors (mGluRs) are a family of class 3 G protein-coupled receptors with important functions in the regulation of synaptic transmission, plasticity, neuronal excitability, and the regulation sensory transduction [ 1 2 3 4 5 ] . The eight mGluRs (mGluR1-8) and their splice variants have been divided into three groups (I-III) based on sequence homology, pharmacology and G protein coupling profiles [ 3 6 7 ] . Group II (mGluR2 and 3) and III (mGluR4, and 6 through 8) couple negatively to adenylate cyclase through activation of the G i/o family of G proteins [ 8 ] . Group I mGluRs (mGluR1 and 5) couple to multiple G proteins in native and heterologous systems, and have been observed to couple to G q/11 , G i/o and/or G s [ 9 10 11 12 13 14 15 ] . mGluRs appear to be important mediators of synaptic transmission in the brain.


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