Words similar to adenoviruses
Example sentences for: adenoviruses
How can you use “adenoviruses” in a sentence? Here are some example sentences to help you improve your vocabulary:
Unfortunately, naive lymphocytes are not susceptible to infection with adenoviruses due to lack of detectable expression of a viral receptor, such as the coxsackie/adenovirus receptor (CAR), which is required for efficient viral attachment [ 8 9 10 ] . The CAR protein contains two extra-cellular immunoglobulin-like (Ig) domains, the first of which appears sufficient for binding to the adenoviral fiber knob protein [ 11 12 ] . Expression of either human or murine CAR in various cell lines has been shown to facilitate gene transfer by recombinant human adenoviruses [ 8 9 10 13 ] . Stable transfection of transformed murine B and T cells lines with human CAR (hCAR) lacking its cytoplasmic domain rendered them susceptible to adenoviral transfection, establishing that lymphoid cells can be permissive hosts for adenoviral transduction and demonstrating that the cytoplasmic domain of CAR is not required for viral entry [ 13 ] . More recently, mice transgenic for full length [ 14 ] or truncated hCAR [ 15 ] have been described in which adenoviral transduction of primary lymphocytes has been demonstrated.
Intramuscular injection of 10 10iu induces moderate local inflammation [ 15 ] . However, the local and systemic toxicity of the adenoviruses can be dramatically reduced by using gutless viruses [ 16 ] . Notably, we observed severe muscle damage after the electric pulse delivery, which was worsened by the pre injection of saline but was not influenced by the presence of plasmid.
It is assumed that the infection of hepatocytes by the adenoviruses is a random event following the Poisson distribution.
The development of newer recombinant adenoviruses containing elements for epichromosomal replication may alleviate limitations that prevent more stable in vivo expression in dividing lymphoid cells derived from hCAR transgenic mice.
After large-scale production, adenoviruses were purified by double cesium chloride gradient [ 7 ] , dialyzed in 10% glycerol/10 mM HEPES/0.
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