Words similar to adenoviruses
Example sentences for: adenoviruses
How can you use “adenoviruses” in a sentence? Here are some example sentences to help you improve your vocabulary:
However, a non-negligible proportion of adenoviruses leaks out of the tumour and reaches the liver.
The development of newer recombinant adenoviruses containing elements for epichromosomal replication may alleviate limitations that prevent more stable in vivo expression in dividing lymphoid cells derived from hCAR transgenic mice.
To test this, we generated recombinant adenoviruses driving the expression of SKP2 (Ad-SKP2) or a mutant of SKP2 lacking the F-box (Ad-SKP2-ΔF).
Unfortunately, naive lymphocytes are not susceptible to infection with adenoviruses due to lack of detectable expression of a viral receptor, such as the coxsackie/adenovirus receptor (CAR), which is required for efficient viral attachment [ 8 9 10 ] . The CAR protein contains two extra-cellular immunoglobulin-like (Ig) domains, the first of which appears sufficient for binding to the adenoviral fiber knob protein [ 11 12 ] . Expression of either human or murine CAR in various cell lines has been shown to facilitate gene transfer by recombinant human adenoviruses [ 8 9 10 13 ] . Stable transfection of transformed murine B and T cells lines with human CAR (hCAR) lacking its cytoplasmic domain rendered them susceptible to adenoviral transfection, establishing that lymphoid cells can be permissive hosts for adenoviral transduction and demonstrating that the cytoplasmic domain of CAR is not required for viral entry [ 13 ] . More recently, mice transgenic for full length [ 14 ] or truncated hCAR [ 15 ] have been described in which adenoviral transduction of primary lymphocytes has been demonstrated.
Adenoviruses
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