Words similar to adenoviruses
Example sentences for: adenoviruses
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Adenoviruses
prepared the SKP2-ΔF mutant, SKP2 adenoviruses, and provided initial evidence for p27 upregulation by MIB.
Briefly, recombinant adenoviruses were generated by homologous recombination in CRE8 cells, a 293 cell line that expresses Cre recombinase, between psi-5, an Ad5-derived, E1- and E3-deleted adenovirus, and pAd-lox, the adenoviral shuttle vector that expresses IL-4.
Unfortunately, naive lymphocytes are not susceptible to infection with adenoviruses due to lack of detectable expression of a viral receptor, such as the coxsackie/adenovirus receptor (CAR), which is required for efficient viral attachment [ 8 9 10 ] . The CAR protein contains two extra-cellular immunoglobulin-like (Ig) domains, the first of which appears sufficient for binding to the adenoviral fiber knob protein [ 11 12 ] . Expression of either human or murine CAR in various cell lines has been shown to facilitate gene transfer by recombinant human adenoviruses [ 8 9 10 13 ] . Stable transfection of transformed murine B and T cells lines with human CAR (hCAR) lacking its cytoplasmic domain rendered them susceptible to adenoviral transfection, establishing that lymphoid cells can be permissive hosts for adenoviral transduction and demonstrating that the cytoplasmic domain of CAR is not required for viral entry [ 13 ] . More recently, mice transgenic for full length [ 14 ] or truncated hCAR [ 15 ] have been described in which adenoviral transduction of primary lymphocytes has been demonstrated.
Intramuscular injection of 10 10iu induces moderate local inflammation [ 15 ] . However, the local and systemic toxicity of the adenoviruses can be dramatically reduced by using gutless viruses [ 16 ] . Notably, we observed severe muscle damage after the electric pulse delivery, which was worsened by the pre injection of saline but was not influenced by the presence of plasmid.
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