Words similar to adenovirus
Example sentences for: adenovirus
How can you use “adenovirus” in a sentence? Here are some example sentences to help you improve your vocabulary:
The adenovirus (AV) backbone for the aquaporin-1 (AQP1) sense and antisense AV constructs was a replication-deficient "first-generation" AV with deletions of the E1 and E3 genes [ 26 ] . This "empty" AV contains the cytomegalovirus (CMV) promoter and bovine growth hormone polyadenylation (bHG) site separated by a polylinker that was used to clone AQP1 DNA as described previously [ 27 ] . A recombinant AQP1 virus was constructed using a plasmid containing the coding sequence for AQP1, pCHIPev [ 28 ] . pCHIPev was digested and the AQP1 insert was subcloned into the shuttle vector pSKAC, creating pSKAC/AQP1.
Unfortunately, naive lymphocytes are not susceptible to infection with adenoviruses due to lack of detectable expression of a viral receptor, such as the coxsackie/adenovirus receptor (CAR), which is required for efficient viral attachment [ 8 9 10 ] . The CAR protein contains two extra-cellular immunoglobulin-like (Ig) domains, the first of which appears sufficient for binding to the adenoviral fiber knob protein [ 11 12 ] . Expression of either human or murine CAR in various cell lines has been shown to facilitate gene transfer by recombinant human adenoviruses [ 8 9 10 13 ] . Stable transfection of transformed murine B and T cells lines with human CAR (hCAR) lacking its cytoplasmic domain rendered them susceptible to adenoviral transfection, establishing that lymphoid cells can be permissive hosts for adenoviral transduction and demonstrating that the cytoplasmic domain of CAR is not required for viral entry [ 13 ] . More recently, mice transgenic for full length [ 14 ] or truncated hCAR [ 15 ] have been described in which adenoviral transduction of primary lymphocytes has been demonstrated.
Measles virus was the first infectious agent shown to induce TRAIL production [ 36 ] . Other studies have demonstrated induction of TRAIL by Theiler's murine encephalomyelitis virus (TMEV) in M1-D cells (a myelomonocytic precursor cell line) [ 37 ] , reovirus infection in fibroblasts [ 38 ] , HIV-1 infection in CD4 +T cells [ 39 ] , and adenovirus in 239T cells [ 40 ] . The demonstration of caspase-8 involvement in S. aureus -induced apoptosis is complemented by a recent report from our laboratory that S. aureus induces expression of TRAIL by infected osteoblasts [ 41 ] . We reported that S. aureus strongly induces TRAIL expression by both normal mouse and normal human osteoblasts, while mRNAs encoding the death-domain-containing TRAIL receptors are constitutively expressed in the same cells.
In case of tumours that are poorly permissive to adenovirus, it is difficult to transduce a large number of tumour cells with adenoviral vectors without inducing severe liver damage.
The adenovirus expressing luciferase was kindly provided by J Kolls (LSU Medical Center, New Orleans, LA, USA).
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