Words similar to adenomas
Example sentences for: adenomas
How can you use “adenomas” in a sentence? Here are some example sentences to help you improve your vocabulary:
p27 Kip1knockout mice display internal organ hyperplasia and are highly prone to pituitary adenomas [ 5 6 7 ] . In human cancers, such as breast [ 8 ] , prostate [ 9 ] , colorectal [ 10 ] , and others, low levels of p27 Kip1expression correlate with decreased survival rates.
The NSAID sulindac has been shown to cause regression of colorectal adenomas of patients with hereditary forms of polyposis (Familial Adenomatous Polyposis (FAP) and Gardner's Syndrome) [ 17 18 19 ] and in sporadic colorectal adenomas [ 20 ] . In addition, case reports have demonstrated that indomethacin and sulindac were effective co-therapy agents in the treatment of desmoid tumours [ 21 22 ] . Finally, the inclusion either of indomethacin, naproxen or sulindac in the chemotherapy regiment of gastric carcinoma patients resulted in a significant increase in survival; 30 months versus 6 months when NSAIDs included in treatment regime [ 22 ] .
Various studies have reported increased levels of prostaglandins and COX-2 expression in colorectal adenomas and adenocarcinomas obtained both from animals [ 40 41 ] and humans [ 42 43 44 ] . These findings have lead to the implication that COX-2 plays an important role in intestinal neoplasia and that the anti-neoplastic effects of NSAIDs are attributable to their ability to inhibit COX-2.
Polyps (multiple) are generally localized to the small intestine in Min /+ mice, opposed to the colons of FAP suffers [ 27 ] . In Min /+ mice adenoma formation is thought to occur within the first few weeks of life, with a full compliment of adenomas being attained by approximately 9 weeks of age (60-67 days of age) [ 6 28 ] . Following this time, adenoma multiplicity is thought not to change, however, adenoma size may still increase [ 6 28 ] . Min /+ mice are also normally found to develop anaemia by 60 days of age and possess a shortened life span of roughly 120 days (17 weeks) [ 29 ] .
Large intestinal adenomas as large as 5-6 mm in diameter were occasionally seen.
Loading...