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Example sentences for: accumulating
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The recF mutation partially suppressed the effect of the recC73 mutation in accumulating the huge linear chromosomes (Figure 2B).
There is accumulating evidence that, in addition to activation-induced cell death or anergy, T-cell-mediated dominant control of self-reactive T cells represents one mechanism for maintaining immunological tolerance [ 1 2 3 ] . Studies conducted in a number of experimental models have demonstrated the existence of regulatory T-cell subsets that prevent activation of autoreactive T cells.
Evidence is accumulating that a number of other factors modulate the actions of gonadotropins in the ovary and testis via activation of alternative signaling pathways and via LHR protein variants, and alternative second messenger pathways for the transmission of the LHR activation effect exist, which may not include stimulation of cyclic AMP levels [ 65 66 67 68 69 ] . A question also arises if the nuclear LHR expression in terminally differentiated cells (e.g.
Some studies also indicate that estrogen receptors reside on the plasma membrane and modulate cellular activity without directly associating with DNA [ 16 ] . Human ERβ is encoded by 477 amino acids (~52 kDa) and has substantial homology to ERα (66 kDa) [ 17 18 ] . Although both estrogen receptors (ERs) can be expressed in various estrogen-sensitive tissues and cells, evidence is accumulating that their expression varies during cellular proliferation and differentiation [ 19 ] . It appears quite clear today that ERβ has biological roles that are distinct from those of ERα, and certain results indicate that ERβ can have effects opposite to those of the ERα [ 20 21 ] .
Phorbol esters are often used as activators of PKC to investigate the role of the kinase in cellular functions [ 1 ] . Accumulating lines of evidence indicates that PMA plays a complex role in regulation of cellular function, including PKC-dependent [ 18 19 20 ] and PKC-independent ways [ 23 24 21 ] . In the present results, PMA inhibited slow membrane depolarization and action potentials in response to glucose stimulation (Fig.
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