Example sentences for: accumulated

How can you use “accumulated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Evidence has been accumulated that TGFβ promotes late-stage tumorigenesis by stimulating angiogenesis and invasive behaviour of tumor cells, enhancing immunosuppression and supporting epithelial-mesenchymal transition of cancer cells [ 4 ] . Furthermore, TGFβ is believed to be part of a vicious circle in bone metastases as it gets released from osteoclast-degraded bone substance and subsequently stimulates PTHrP gene expression in nearby metastatic cancer cells which in turn leads to an activation of osteoclastic bone resorption [ 11 ] . Therefore, it is of great interest to understand in more detail the molecular aspects of TGFβ-mediated gene expression in metastatic breast cancer cells and to explore ways to interfere with this tumorigenic signalling.

  • As a result, Social Security benefits must be supplemented by private pensions, accumulated assets, or other resources in order for individuals to maintain a reasonable standard of living in retirement compared to their final working years.

  • A further problem is that the wealth of knowledge accumulated after decades of biological research has resulted in a considerable narrowing of research fields.

  • They accumulated an ill-defined pericellular matrix and the osteoblast-specific protein osteocalcin (Fig.

  • Other pseudogenes may have been inactivated relatively recently in evolutionary history, and may show substantial codon-preserving bias accumulated over the evolutionary period during which the gene was functional.


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