Words similar to translocation
Example sentences for: translocation
How can you use “translocation” in a sentence? Here are some example sentences to help you improve your vocabulary:
Consequently, our results demonstrate in living cells that the translocation process and subsequent catalytic activity on the membrane are two independently regulated steps.
The signal sequence is crucial for efficient translocation; mutations in the signal sequence significantly reduce export of the preprotein and complete deletions of the signal sequence eliminate essentially all export [ 5 6 7 8 ] . Selection for extragenic suppressors of such export defective preproteins led to the identification of the prl alleles of secY ( prlA ), secE ( prlG ), secA ( prlD ), and more recently secG ( prlH ) [ 6 9 10 11 ] . Early hypotheses predicted that the Prl suppressors function by expanded or altered interactions with signal sequences, facilitating recognition of mutant as well as wild type signal sequences [ 6 ] .
In each of the enumerated studies, a minimum of 12 explants were cultured for 2 or 4 days in the cell permeable peptide SN50 (Biomol Research, Plymouth Meeting, PA) which inhibits NF-κB translocation into the nucleus [ 24 33 34 35 ] . The concentration used (100 μg/ml) was double that shown to inhibit NF-κB translocation in mouse endothelial LE-II cells; 100 μg/ml mutant SN50 (mSN50) peptide was used as a positive control and control BGJb medium as a negative control.
Smad1, as one of the three known R-Smads of BMPs, has been extensively studied within the scope of its phosphorylation, interaction with Smad4, nuclear translocation, DNA binding and protein-protein interactions related to its function as a transcriptional regulator.
Specifically, nuclear translocation of NF-κB and mitogen-activated protein kinase (MAPK) stimulation of activator protein-1 (AP-1) are required for transcription of cytokine-induced MMP-1 and MMP-13.
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