Words similar to translocation
Example sentences for: translocation
How can you use “translocation” in a sentence? Here are some example sentences to help you improve your vocabulary:
E15 SMG primordia were cultured for 2 days in the presence or absence of the cell-permeable peptide SN50, a potent inhibitor of NF-κB nuclear translocation [ 33 34 35 ] . SN50 is composed of a nuclear localization sequence (NLS) for NF-κB p50 linked to a cell-permeable carrier [ 33 34 35 ] . SN50 blocks the intracellular recognition mechanism for the NLS on NF-κB, thus inhibiting NF-κB's translocation through the nuclear pore.
It has recently been shown that SB-202190 and SB-203580 are able to inhibit TGFβ-induced phosphorylation of Smad3 by the TGFβ-receptor I kinase (ALK5) and to interfere with nuclear localization of Smad3 [ 17 ] . Nuclear translocation of Smad3 results directly from TGFβ-induced Smad3 phosphorylation and is, therefore, a measure of the activation status of ALK5.
However, yeast deletion mutants lacking all the p24 proteins grow similarly to wild type, although they show delays in translocation of a subset of cargo molecules such as invertase and Gas1p from the ER to the Golgi, and increased secretion of resident ER proteins [ 18].
A variety of factors complicate this relatively simple model, including the specific cytoplasmic to nuclear translocation that is required for CAR transactivation in the liver [ 22 23 ] . Rexinoids by themselves are apparently unable to induce this translocation process in rat [ 17 ] or mouse (data not shown) hepatocytes and thus cannot directly activate CAR targets.
Released NF-κB dimers then translocate to the nucleus, bind to its cognate DNA elements, and induce the expression of target genes [ 23 24 25 ] . Activated, nuclear translocated, NF-κB transcription factor has been documented in the mouse embryo from the 1-cell stage onward [ 26 27 ] . Activated NF-κB translocation into the nucleus, directly or indirectly, effects the transcriptional control of over 150 target genes [ 28 ] . NF-κB enhances cell proliferation by stimulating the expression of cytokines such as TNF, IL-1, IL-2, IL-6, and IL-8, among others [ 28 29 ] ; NF-κB inhibits apoptosis by inducing TRAF and clAP expression which suppresses Caspase 8 activation [ 30 ] , and by inhibition of p53 transactivation [ 31 32 ] .
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