Words similar to translocations
Example sentences for: translocations
How can you use “translocations” in a sentence? Here are some example sentences to help you improve your vocabulary:
The proto-oncogene TEL (Translocation, Ets, Leukemia) is a transcriptional repressor that contains a C-terminal Ets family DNA binding domain; a central domain that together with co-repressors recruit histone deacetylases [ 1 2 3 ] ; and an N-terminal SAM (sterile, alpha, motif) domain [ 4 5 6 ] , which we have recently shown forms a polymer [ 7 ] . Chromosomal translocations in a variety of leukemias result in fusion of the SAM domain of TEL to tyrosine kinase domains such as ABL, PDGFβ and JAK2 [ 8 9 10 11 12 13 14 ] or to the transcriptional activators AML1 and ARNT [ 15 16 17 ] . In the tyrosine kinase fusions, SAM domain polymerization leads to constitutive activation of the tyrosine kinase domains, which leads in turn to cell transformation [ 10 12 18 19 ] . Thus, compounds that block TEL-SAM polymerization could be effective in treating these leukemias.
It associates specifically with unduplicated centrosomes, and its phosphorylation by CDK-2/cyclin E, the trigger for centrosome duplication, is required for duplication to occur [ 17 ] . The nucleophosmin gene is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase in cases of this disease with (2;5)(p23;q35) translocations [ 18 ] . The nucleophosmin portion contributes to transformation by providing a dimerization domain, which allows activation of the fused kinase and signal transduction [ 19 ] .
Whereas the duplications and translocations outline mechanisms that have contributed to the evolution of the large AQP gene family, the large number of genes and the transcription patterns we found in the EST database (see below) seems to argue for specific functions in plants.
This was true for Shab ( Dm 3L, Ag 2L), Shaw ( Dm 2L, Ag 3R), Shal ( Dm 3L, Ag 2L), KCNQ ( Dm 2R, Ag 2L) and Slowpoke ( Dm 3R, Ag 2R), as well as for Slack , eag , erg , elk , and the three inward rectifier genes, as shown in Table 2. The translocations between autosomes and chromosome X, observed for eag and Hyperkinetic , are notable: these examples raise questions about dosage compensation which will need to be addressed in future studies.
Many other associated mutation or amplification of oncogenes, tumor suppressor genes including p53, K-ras, N-ras and N-myc, etc. are frequently seen, but the roles of these gene mutations/amplifications in pathogenesis of the tumor remain largely unclear [ 4 ] ; [ 5 ] . The alveolar subtype of rhabdomyosarcoma, however, is consistently associated with two common chromosomal translocations.
Loading...