Example sentences for: translocates

How can you use “translocates” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • While expression of wild-type human protein does not significantly alter overall β-catenin levels, stabilized protein accumulates in hippocampal, cortical and cerebellar neurons and translocates into their nuclei.

  • Although this mutant translocates to mitochondria as efficiently as does the WT with diminished disruptive effect on the outer membrane, it seems conceivable that tBid harbors two distinct signals, one for translocation to mitochondria, and the other for interaction with proteins or lipids to exert its pro-apoptotic function.

  • Upon treatment with the calcium ionophore ionomycin, GFP-NFAT translocates rapidly to the nucleus.

  • An amino terminal, calcium-dependent lipid binding (CaLB or C2) domain regulates Ca 2+-mediated cPLA 2 translocation to intracellular membranes [ 9 ] . In vitro, membrane docking via the C2 domain is necessary and sufficient for catalysis and release of AA [ 10 ] . Binding of calcium ions by the cPLA 2 C2 domain is essential for the lipid association in vitro [ 11 12 ] and translocation in vivo [ 13 14 ] . In response to an increase in [Ca 2+] i , cPLA 2 translocates to the Golgi and ER, however translocation to Golgi occurs at a lower [Ca 2+] i [ 15 ] .

  • cPLA 2 translocates primarily to Golgi in response to a transient [Ca 2+] i changes and to Golgi and ER in response to a sustained [Ca 2+] i increase [ 15 ] . The reduction in AA release by MEK inhibition did not involve a failure in [Ca 2+] i release or translocation.


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