Example sentences for: translocates

How can you use “translocates” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Upon treatment with the calcium ionophore ionomycin, GFP-NFAT translocates rapidly to the nucleus.

  • In response to physiological agonists that elicit transient [Ca 2+] i changes, only a small fraction of the cPLA 2 translocates.

  • Cyp 1 transcription is activated when cytosolic hydrocarbons activate the Ah receptor which then translocates to the nucleus and heterodimerizes with Arnt, leading to binding to an upstream xenobiotic response element on Cyp 1. Cyps 2-4 are induced through nuclear hormone receptors.

  • In addition, IFNg interaction with the receptor leads to p38MAPK-mediated phosphorylation of STAT1 on Serine 727 [ 17 ] . The phosphorylated STAT1 dimerizes and translocates into the nucleus where it activates transcription of several other factors including CIITA [ 31 ] . Although the results of this study do not allow us to describe the exact mechanism of PMA involvement in IFNg signalling in LS1034 cell, at least two non-mutually exclusive scenarios can be hypothesized:

  • Upon agonist binding, the complex undergoes a transformation, and the ligand bound GR translocates into to the nucleus in a manner that is determined by a nuclear localization sequence (NLS) contained in the receptor [ 4].


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