Words similar to smad

Example sentences for: smad

How can you use “smad” in a sentence? Here are some example sentences to help you improve your vocabulary:

C. G. carried out the domain mapping studies for Az interaction with Smad1 and HsN3.
The smad7 gene contains a perfect palindromic Smad binding element (GTCTAGAC) while the pai-1 and the pthrp promoters harbor AGAC tandem repeats [ 19 33 ] which binds Smad proteins less efficiently [ 34 ] . The upa gene contains only an AP1-binding site which resembles the Smad3/4-responsive AGAC motif [ 35 ] . A weaker binding site could require Smad3 to be present at higher concentrations for efficient binding and would make TGFβ-dependent transcription from a gene more vulnerable to reduced nuclear accumulation of the Smad3 protein.
In several cell lines, particularly in pancreatic carcinoma cells, resistance to TGFβ 1 could be attributed to a loss of function of the SMAD4 (DPC4) protein [ 40 41 42 43 ] . However, the pancreatic carcinoma cell line BxPC-3, although homozygously deleted for SMAD4, is growth inhibited by TGFβ 1 [ 30 44 ] . It is thus speculated that alternative signaling pathways in addition to the SMAD pathway may exist.
BMP type I receptor activation induces SNIP1 degradation that is regulated by Smad1, Smad4 and Az
To exclude this possibility, cellular proteins were divided into cytoplasmatic and nuclear fractions after TGFβ 1 stimulation, and localization and phosphorylation of SMAD2/3 were investigated.