Words similar to smad

Example sentences for: smad

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Az was previously identified as a polyamine-inducible factor that binds and targets the ornithine decarboxylase (ODC) to proteasome for degradation [ 18 45 ] . Until now, ODC is the only protein known to be targeted by Az to proteasome, although the existence of additional proteins targeted by Az to proteasome has been suspected [ 20 ] . We now find two new Az interactors: Smad1, the key signal transducer of BMPs, as well as SNIP1, the nuclear repressor of CBP/p300.
For example, the protein levels of Smad1, Smad4 and Az were all sensitive to lactacystin (Fig.
TGFβ signals through a heteromeric receptor complex of type II and type I receptor serine-threonine kinases, which activates the downstream Smad signal transduction pathway [ 7 ] . After TGFβ binding to the receptor complex, the TGFβ type II receptor kinase phosphorylates TGFβ type I receptor which inititates the downstream response by phosphorylating receptor-regulated Smads (R-Smads), such as Smad2 and Smad3.
Two separate domains on Az mediate interaction with Smad1 and HsN3 prior to HsN3 incorporation into the 20S proteasome
4B, Pro-N3-F was specifically detected in the immunoprecipitates of Smad1 but not those of Smad2.