Words similar to sm-mhc
Example sentences for: sm-mhc
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Our findings are consistent with those of a recent study showing that a vast majority of the ME cells in both normal and ductal carcinoma in situ displayed distinct immunostaining to p63, SM-MHC, and calponin, whereas a single or a cluster of a few ME cells in some ducts failed to show immunoreactivity to all these three markers [ 28 ] . However, our study differs from this study [ 28 ] and previous studies [ 3 4 ] in four aspects: first, the SMA-negative cells were segmented, accounting for at least one-third or all of the ME cells in involved ducts; second, we tested for more ME cell markers; third, the SMA-negative cells assessed were morphologically similar to their adjacent SMA-positive neighbors on H&E-stained sections; fourth, our focus is directed toward the elucidation of the detailed immunohistochemical profile of these SMA-negative cells identified in 3 of 175 examined cases.
Nine antibodies reported to present exclusively or preferentially at ME cells were selected for this study [ 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 ] (Table 1); these included antibodies against SMA, smooth muscle myosin heavy chain (SM-MHC), CD10, calponin, protease inhibitor 5 (maspin), Wilms' tumor-1 (WT-1), and cytokeratins 5, 14, and 17 (CK5, CK4, and CK17).
CK = cytokeratin; ER = estrogen receptor; H&E = hematoxylin/eosin; ME = myoepithelial; SMA = smooth muscle actin; SM-MHC = smooth muscle myosin heavy chain; WT-1 = Wilms' tumor-1.
In double immunostained sections, these SMA-negative cells were also negative for SM-MHC, WT-1, CD10, and calponin (Fig.
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