Words similar to sma-negative
Example sentences for: sma-negative
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In double immunostained sections, these SMA-negative cells were also devoid of distinct immunostaining for any of the additional eight markers (Fig.
It has been reported that the exposure to lambdacarrageenan could specifically result in filament disassembly and loss of ME cells [ 34 ] . In contrast, exposure to oxytocin could substantially enhance ME cell differentiation and proliferation in mouse breasts [ 35 ] . In addition, these SMA-negative ME cells might be newly formed through stem-cell-mediated proliferation and are in the transition to a terminally differentiated status.
The SMA-positive and SMA-negative cells were morphologically indistinguishable on H&E-stained sections.
Our assumption is in agreement with our previous findings, which have revealed that focal disruptions of ME cell layers could lead to a significantly higher proliferation rate in subjacent epithelial cells [ 12 33 ] . Our assumption is also supported by a recent study showing that normal and tumor-derived ME cells differ substantially in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition [ 37 ] . Further studies are currently in progress to elucidate the biological behavior and genetic profile of epithelial cells immediately subjacent to these SMA-negative ME cells.
Our findings are consistent with those of a recent study showing that a vast majority of the ME cells in both normal and ductal carcinoma in situ displayed distinct immunostaining to p63, SM-MHC, and calponin, whereas a single or a cluster of a few ME cells in some ducts failed to show immunoreactivity to all these three markers [ 28 ] . However, our study differs from this study [ 28 ] and previous studies [ 3 4 ] in four aspects: first, the SMA-negative cells were segmented, accounting for at least one-third or all of the ME cells in involved ducts; second, we tested for more ME cell markers; third, the SMA-negative cells assessed were morphologically similar to their adjacent SMA-positive neighbors on H&E-stained sections; fourth, our focus is directed toward the elucidation of the detailed immunohistochemical profile of these SMA-negative cells identified in 3 of 175 examined cases.
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