Words similar to smac

Example sentences for: smac

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Our previous study showed that functional decline of mitochondria appears in the SOD1 G93Amice as early as 60 to 100 days of age [ 22 ] . This precedes the peak of mitochondrial vacuolation and the onset of the disease by two to three months [ 15 ] . Mitochondrial dysfunction can lead to energy deficiency and ionic imbalance [ 68 ] , elevated ROS and oxidative damage [ 69 ] , and increased sensitivity of neurons to excitotoxicity [ 19 70 71 72 ] . These effects could precipitate MVISE, which trigger cell death programs by releasing pro-apoptotic proteins resided in the mitochondrial intermembrane space, such as cytochrome c, AIF, SMAC/DIABLO, endo G and Htra/Omi [ 73 ] . The absence of cytochrome c in the porous large vacuoles and the presence of cytochrome c in the small vacuoles (Fig.
DIABLO, also known as SMAC (second mitochondria-derived activator of caspase), promotes caspase activation in a cytochrome c-APAF1-CASP9 pathway [ 5 ] .
Recent work has shown that the Bcl-2 family regulates mitochondrial homeostasis during apoptosis [ 1 ] . Pro-apoptotic members, including Bax, Bak, Bid, and Bim, promote the release of death-inducing proteins, such as cytochrome c [ 2 3 ] , smac [ 4 ] , and endonuclease G [ 5 ] , from mitochondria while anti-apoptotic members, such as Bcl-2 and Bcl-X L , inhibit this release.