Words similar to smads
Example sentences for: smads
How can you use “smads” in a sentence? Here are some example sentences to help you improve your vocabulary:
Three such BMP type I receptor-regulated Smads, Smad1, 5 and 8, have been identified [ 9 ] . Among them, Smad1 has been studied most extensively.
The chaperon proteins such as Hsc73 could be involved in unfolding the substrates for them to fit into the degradation chamber and the final maturation of 20S proteasome from the 16S assembly intermediates could trap the substrates, such as Ump1 and Smads, inside the degradation chamber.
TGFβ signals through a heteromeric receptor complex of type II and type I receptor serine-threonine kinases, which activates the downstream Smad signal transduction pathway [ 7 ] . After TGFβ binding to the receptor complex, the TGFβ type II receptor kinase phosphorylates TGFβ type I receptor which inititates the downstream response by phosphorylating receptor-regulated Smads (R-Smads), such as Smad2 and Smad3.
Instead of independently binding to specific DNA sequence to regulate transcription, Smads are now considered to be transcriptional modulators since their ability to regulate transcription is dependent, in most cases, on their physical interaction with other nearby DNA-binding transcription factors [ 11 ] . Thus, one of the fundamental questions in understanding Smad-regulated transcription is how Smads function as transcription modulators.
ets-1, ets-2 and ese-1/esx . Smad7 was of particular interest as it belongs to the inhibitory Smads, which can counteract TGFβ-induced gene activation [ 23 ] . The response of the smad7 gene to TGFβ is unusually rapid [ 24 ] which is believed to stem from the peculiar nature of the Smad7 promoter that contains a "perfect" Smad binding site [ 25 ] . Another inhibitory Smad protein is Smad6.
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