Example sentences for: smads

How can you use “smads” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Three such BMP type I receptor-regulated Smads, Smad1, 5 and 8, have been identified [ 9 ] . Among them, Smad1 has been studied most extensively.

  • The subject of proteasomal degradation of Smads and Smad interacting proteins has now become a major focus of interest in the field due to its broad implication in signaling regulation and execution.

  • Considering the sophisticated mode of regulation characteristic of the TGF-β/BMP family ligands, it is expected that that signaling mechanisms of Smads should have a nature of complexity that can accommodate the vast biological functions of these regulators.

  • TGFβ signals through a heteromeric receptor complex of type II and type I receptor serine-threonine kinases, which activates the downstream Smad signal transduction pathway [ 7 ] . After TGFβ binding to the receptor complex, the TGFβ type II receptor kinase phosphorylates TGFβ type I receptor which inititates the downstream response by phosphorylating receptor-regulated Smads (R-Smads), such as Smad2 and Smad3.

  • Smads have been shown to mediate transcription via modulating the transcriptional activity of many other DNA-binding proteins.


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