Example sentences for: smads

How can you use “smads” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • However, our current knowledge of the molecular events involved in the recruitment of CBP/p300 and other transcriptional co-activators or co-repressors by Smads is still very limited.

  • Three such BMP type I receptor-regulated Smads, Smad1, 5 and 8, have been identified [ 9 ] . Among them, Smad1 has been studied most extensively.

  • Smads have been shown to mediate transcription via modulating the transcriptional activity of many other DNA-binding proteins.

  • The requirement of both Smad1 and Smad4 in the down-regulation of SNIP1 is interesting since this may represent an important molecular mechanism for the co-operative property of these Smads to modulate transcription.

  • Instead of independently binding to specific DNA sequence to regulate transcription, Smads are now considered to be transcriptional modulators since their ability to regulate transcription is dependent, in most cases, on their physical interaction with other nearby DNA-binding transcription factors [ 11 ] . Thus, one of the fundamental questions in understanding Smad-regulated transcription is how Smads function as transcription modulators.


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