Words similar to smads
Example sentences for: smads
How can you use “smads” in a sentence? Here are some example sentences to help you improve your vocabulary:
The subject of proteasomal degradation of Smads and Smad interacting proteins has now become a major focus of interest in the field due to its broad implication in signaling regulation and execution.
Instead of independently binding to specific DNA sequence to regulate transcription, Smads are now considered to be transcriptional modulators since their ability to regulate transcription is dependent, in most cases, on their physical interaction with other nearby DNA-binding transcription factors [ 11 ] . Thus, one of the fundamental questions in understanding Smad-regulated transcription is how Smads function as transcription modulators.
However, we propose that such degradation is coupled to the recruitment of the SNIP1-free CBP/p300 to a nearby DNA-binding transcription factor, thus carrying out the commonly observed role of Smads as transcriptional co-modulators.
ets-1, ets-2 and ese-1/esx . Smad7 was of particular interest as it belongs to the inhibitory Smads, which can counteract TGFβ-induced gene activation [ 23 ] . The response of the smad7 gene to TGFβ is unusually rapid [ 24 ] which is believed to stem from the peculiar nature of the Smad7 promoter that contains a "perfect" Smad binding site [ 25 ] . Another inhibitory Smad protein is Smad6.
To date, expression of TGF-β receptors and downstream signaling components such as the Smads have not been well-characterized in this rat model, but in our preliminary analyses we saw no effect of retinoids on type I and type II TGF-β receptor expression in the mammary gland (data not shown).
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