Example sentences for: small-molecule

How can you use “small-molecule” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • As might have been anticipated in treatment of cancer with any single agent, resistance to small-molecule tyrosine kinase inhibitors has emerged as a significant clinical problem.

  • Recently, new small-molecule inhibitors have been identified that retain activity against the majority of imatinib-resistant BCR-ABL mutants.

  • These hybrid molecules activate transcription [ 9 31 ] . It may be possible to produce small-molecule activators (or repressors) that bind DNA specifically, but also activate transcription of adjacent genes through a non-peptidic, more drug-like moiety.

  • In this article, we show that a non-peptidyl small-molecule agonist of Hh signaling has been identified that has all the known signaling properties of the recombinant Hh protein.

  • This supports the model that all of these small-molecule modulators of Hh signaling are direct ligands of Smo.


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