Example sentences for: small-molecule

How can you use “small-molecule” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The original report on the crystal structure of the photosynthetic reaction center suggested that the region corresponding to the PRC-barrel of the PRC-H subunit could bind a small-molecule ligand [ 14].

  • Folds such as the SH3-like barrels, the PAS-like fold, the OB fold, the double-stranded β-helix, the β-propeller and rubredoxin-like zinc ribbons are predominantly non-catalytic domains that are widely represented in multiple functional contexts, with roles such as small-molecule binding, nucleic-acid binding and interaction with other proteins [ 3, 4, 5] (see also the SCOP [ 6] and CATH [ 7] databases).

  • These observations suggest that the Ptc-Smo receptor circuit may incorporate native small-molecule ligands in the regulation of Hh signaling.

  • Furthermore, studies with the agonist and several antagonists of Hh signaling suggest that Smo can be activated or inhibited by direct interaction with small-molecule ligands.

  • To identify small-molecule agonists of Hh signaling, we established a mammalian-cell-based assay.


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