Example sentences for: smad-

How can you use “smad-” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In contrast, treatment with BMP-5 did not alter levels of total Smad-1 (Figure 4B).

  • In this report we demonstrate that BMP-5 similarly induces Smad-1 phosphorylation in sympathetic neurons as detected by Western blot analyses using antibodies specific for the phosphorylated form of Smad-1.

  • BMPs activate Smad-1 by binding to type I and type II serine-threonine kinase receptors [ 40 41 ] . Specific receptor subunits shown to bind BMPs include BMP receptor type IA (BMPR-IA), BMPR-IB, BMR-II, activin receptor type I (ActR-I), and ActR-II [ 42 43 44 ] . BMP ligands can bind to either type I or type II receptor subunits independently, but both receptor types are required for high-affinity binding and signaling [ 40 ] . The finding that the soluble BMPR-IA-Fc chimera significantly inhibits BMP-5 induced dendritic growth suggests that BMP-5 may be activating the Smad-1 signaling pathway via interactions with BMPR-IA.

  • 5 μg/ml for BMP-5 Ab; 10 μg/ml for Smad-1 Ab).

  • The molecular mechanism(s) of BMP-induced dendritic growth downstream of Smad-1 activation are not well characterized.


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