Words similar to smad-

Example sentences for: smad-

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In contrast, treatment with BMP-5 did not alter levels of total Smad-1 (Figure 4B).
In most cell systems that have been examined, the primary signal transduction pathway for BMPs involves phosphorylation of Smad-1 [ 22 ] , and recent evidence suggests that this is also true for BMP-7 induced dendritic growth in sympathetic neurons [ 23 ] . To determine if BMP-5 initiates similar signaling events in sympathetic neurons, cultured sympathetic neurons grown in the absence of glial cells were treated with BMP-5 for 30 or 60 min then analyzed by Western blotting using Abs specific for total Smad-1 or for phosphorylated Smad-1.
Phosphorylation of Smad-1 is evident within 30 min after exposure to BMP-5 (Figure 4A) with significantly increased pSmad-1 levels apparent at 60 min.
The molecular mechanism(s) of BMP-induced dendritic growth downstream of Smad-1 activation are not well characterized.
Data from western blot analyses using Ab specific for phosphorylated epitopes of Smad-1 as well as analyses of dendritic growth in cultures exposed to BMP-5 in the presence of a soluble BMPR-IA-Fc chimeric protein are consistent with a signaling pathway that involves binding to the BMPR-IA and activation of Smad-1.