Words similar to smad-
Example sentences for: smad-
How can you use “smad-” in a sentence? Here are some example sentences to help you improve your vocabulary:
In this report we demonstrate that BMP-5 similarly induces Smad-1 phosphorylation in sympathetic neurons as detected by Western blot analyses using antibodies specific for the phosphorylated form of Smad-1.
The molecular mechanism(s) of BMP-induced dendritic growth downstream of Smad-1 activation are not well characterized.
BMPs activate Smad-1 by binding to type I and type II serine-threonine kinase receptors [ 40 41 ] . Specific receptor subunits shown to bind BMPs include BMP receptor type IA (BMPR-IA), BMPR-IB, BMR-II, activin receptor type I (ActR-I), and ActR-II [ 42 43 44 ] . BMP ligands can bind to either type I or type II receptor subunits independently, but both receptor types are required for high-affinity binding and signaling [ 40 ] . The finding that the soluble BMPR-IA-Fc chimera significantly inhibits BMP-5 induced dendritic growth suggests that BMP-5 may be activating the Smad-1 signaling pathway via interactions with BMPR-IA.
Phosphorylation of Smad-1 is evident within 30 min after exposure to BMP-5 (Figure 4A) with significantly increased pSmad-1 levels apparent at 60 min.
It has been shown that phosphorylation of Smad-1 precedes dendritic extension in cultured sympathetic neurons exposed to BMP-7; moreover, expression of a dominant negative construct of Smad-1 in cultured sympathetic neurons significantly inhibits BMP-7-induced dendritic growth in these neurons [ 23 ] . These data suggest that activation of Smad-1 is a necessary component of the signal transduction pathway by which BMP-7 induces dendritic growth.
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