Words similar to ras
Example sentences for: ras
How can you use “ras” in a sentence? Here are some example sentences to help you improve your vocabulary:
PIP3: Phosphatidyl-3,4,5-triphosphate; DMEM: Dulbecco's Modified Eagle's Medium; PI-3Kinase: phosphatidylinositol-3-kinase; MAPK: mitogen-activated protein kinase; IGF: insulin-like growth factor; PTEN: phosphatase and tensin homolog deleted from chromosome 10; SOS: son-of-sevenless ras exchange factor; ASK: apoptosis stimulating kinase; FKHR: forkhead related protein; cFLIP: cellular FLICE interacting protein; BSA: bovine serum albumin; TBS: tris buffered saline; PVDF: polyvinylidene difluoride
Except epithelium surface, no p53 and ras expression was detected in differentiating epithelial cells.
In this study, we show that p35-C/EBPβ and the TCF family member Elk-1 synergize in transactivation of SRF dependent transcription of both a Gal4 dependent reporter and an SRE-driven reporter construct, but only in response to mitogenic stimulation by Ras.
One of the hallmarks of cancer includes the accumulation of mutations in key genes, namely DNA repair genes [ 4 ] , tumor suppressor genes [ 5 6 ] , and proto-oncogenes [ 5 6 ] , accompanied by the loss of the wildtype allele, resulting in loss of heterozygosity [LOH, see reviews by [ 7 8 9 ] ]. Pancreatic cancer, which results in the death of approximately 30,000 Americans annually and is the fourth leading cause of cancer mortalities in the United States, exhibits this hallmark [ 10 ] . For example, in pancreatic cancer there is a high incidence of mutations (>50%) in the tumor suppressor genes p16, p53 and DPC4 and approximately 90% of cases coincide with a mutation in the oncogene K- ras 2 [see review by [ 11 ] ]. Furthermore, a significant percentage of tumors harboring a mutated copy of DPC4 or p53 also lose the corresponding wildtype allele, resulting in LOH [see reviews by [ 11 12 ] ].
It should be noted that polony amplification of genomic DNA from strains with equal p53 and K- ras 2 copy numbers, such as CAPAN-1, yielded equivalent numbers of p53 and K- RAS 2 polonies (data not shown).
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