Words similar to ras
Example sentences for: ras
How can you use “ras” in a sentence? Here are some example sentences to help you improve your vocabulary:
binding of phosphorylated p27 to SKP2 [ 20 21 ] . SKP2 is down-regulated in resting cells with stable p27, but strongly up-regulated in cells, which progress into S phase [ 27 28 ] . In some tissue culture cells, overexpression of SKP2 is sufficient to induce p27 degradation and S phase entry [ 29 30 31 32 ] , and can cooperate with ras in transformation [ 33 34 ] . Significantly, overexpression of SKP2 has been observed in many cancer cell lines [ 28 35 ] as well as in primary cancer specimens and many of these tumors also display down-regulation of p27 [ 33 36 37 38 ] .
It is well established that mutations affecting the guanine nucleotide state of Ras are associated with neoplastic transformation of mammalian cells [ 35 72 73 ] . However, the potential role of Rab mutations in disease is just beginning to be explored.
In some cases, an accompanying illustration displays the alphabets available; for example, the Alaph [ sic ] Beth Font Kit includes Aramaic (Fourth, Sixth, Eighth, and Ninth century fonts), Assyrian/Babylonian, Coptic, Cuneiform (Ras Shamra and Ugaritic), Hieroglyphics (+850), North Semitic, Phoenician, Sabæan, and Syriac (Estrangelo, Serto, and Eastern scripts).
In addition to the cell line Panc-1, K- ras 2 mutations in the second position of codon 12 were also shown to be present in the cell lines AsPC-1 (G → A; data not shown) and CAPAN-1 (G → T; data not shown).
Cells transformed with mutated ras exhibit a defect in the signal transduction pathway regulating p53 function and alteration in the expression of apoptotic (bax) or anti-apoptotic proteins (bcl-2) [ 20].
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