Words similar to rarα
Example sentences for: rarα
How can you use “rarα” in a sentence? Here are some example sentences to help you improve your vocabulary:
An RARα clone truncated after amino acid 403 was effective in repressing reporter gene activity and blocking wild type RAR function [ 10 11 ] . A single amino acid change in RARα (G303E) impaired RA binding affinity and significantly reduced reporter gene activity from responsive promoters.
Triplicate dishes of SCC25 cells were transiently transfected with 5 μg luciferase reporter construct containing a heterologous promoter containing a consensus AP-1 site 5'-TGACTCA-3' [ 11 ] . 2 μg of wild type or S77A mutant RARα expression vector was cotransfected to determine the effects of RARα phosphorylation on AP-1 promoter activity.
We concluded that decreased RARα phosphorylation produces inhibition of proliferation in SCC25 cells.
The mechanisms which regulate cyclin H/cdk7 phosphorylation of RARα have not been elucidated.
Previous studies have shown that the amino terminus of the estrogen receptor is phosphorylated by MAPK proteins [ 12 ] . To determine the participation of MAPKs in RARα phosphorylation, we performed RARα immunoprecipitation on SCC25 cells treated with the MEK/ERK inhibitor PD98059 or p38 inhibitory drug SB203580.
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