Example sentences for: rarα

How can you use “rarα” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • By comparison, there were no significant differences in BrdU incorporation between HA tagged RARα clones and G418 resistant control cells.

  • These experiments indicate that the relative amount of phosphorylated RARα in SCC25 cells was decreased by the S77A mutant.

  • These results indicate that hypophosphorylated RARα can mimic the effects of RA by inhibiting AP-1 activity.

  • Mutation of serine 77 to alanine in RARα has been shown to inhibit the basal activation function of the receptor [ 7 ] . Other mutations have also been shown to decrease RAR function.

  • Previously we characterized another RARα mutant in which the receptor protein was truncated after amino acid 403, thereby deleting the AF-2 domain [ 11 ] . This truncated receptor exhibited similar properties to the S77A mutant (growth inhibition and repression of RA responsive gene expression including EGFR).


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