Words similar to rars
Example sentences for: rars
How can you use “rars” in a sentence? Here are some example sentences to help you improve your vocabulary:
Each gene may express several different isoforms because of alternative splicing and differential promoter usage [ 2 ] . Both the RARs and RXRs contain functional domains for DNA and ligand binding, dimerization with other transcription factors, and transactivation of RA responsive promoters.
RARs and RXRs function as heterodimers that bind to response elements in the promoters of target genes to regulate RA dependent transcription.
A similar mechanism may also pertain for the effects of T on RAR γ since the DNA binding domains are highly homologous among RARs.
The RARα amino terminus is not known to interact with CBP or its associated factor PCAF [ 5 18 ] . Additionally, RARs bind to the interaction domains of repressor proteins such as NCoR via region D of the receptor rather than the amino terminus [ 4 ] . Despite the lack of obvious interaction of the RAR amino terminus with nuclear receptor cofactors, the S77A mutation may alter the three dimensional structure of the receptor.
Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are nuclear transcription factors that mediate the action of retinoids [ 11 12 ] . We have demonstrated that in the rat, castration resulted in an increase in mRNAs for RAR α and γ in the prostate; such effects were prevented by T replacement [ 13 ] . We also demonstrated that the levels of mRNAs for RAR α and γ in non-tumorigenic rat epithelial cells (NRP152) were down-regulated, whereas those in tumorigenic cells (NRP154) were unaffected or up-regulated following T treatment [ 14 ] . In addition, RAR α was over-expressed in tumorigenic NRP154 cells.
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