Words similar to rars
Example sentences for: rars
How can you use “rars” in a sentence? Here are some example sentences to help you improve your vocabulary:
Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are nuclear transcription factors that mediate the action of retinoids [ 11 12 ] . We have demonstrated that in the rat, castration resulted in an increase in mRNAs for RAR α and γ in the prostate; such effects were prevented by T replacement [ 13 ] . We also demonstrated that the levels of mRNAs for RAR α and γ in non-tumorigenic rat epithelial cells (NRP152) were down-regulated, whereas those in tumorigenic cells (NRP154) were unaffected or up-regulated following T treatment [ 14 ] . In addition, RAR α was over-expressed in tumorigenic NRP154 cells.
It is also possible that TAF II 135 expression modulates the activity of transcription factors in addition to the RARs leading to the appearance of this novel cell type.
The current experiments investigate the effects of T and its interaction with RA on cell growth and the expression of RARs in human prostate cancer cells, LNCaP.
Generally, NR transcriptional activity is dictated by the balance between coactivator and corepressor recruitment, and one of the most important factors that influences this balance is the absence or presence of agonist ligands (reviewed in [ 4 ] ). Unliganded NRs such as thyroid (TRs) and retinoid receptors (RARs) bind corepressors, and ligand promotes release of corepressor and subsequent binding of coactivators.
These findings suggest that tumorigenic transformation and perhaps neoplasia of prostate epithelial cells are associated with abnormal expression and androgen regulation of RARs.
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