Words similar to rars
Example sentences for: rars
How can you use “rars” in a sentence? Here are some example sentences to help you improve your vocabulary:
In any case, the fact that ERβ binds weakly or not at all to the three N-CoR ID motifs that mediate interactions with TRs and RARs and, instead, binds in an agonist-dependent fashion to a region in the C-terminus of N-CoR that has not previously been implicated in NR interactions indicates that ERβ recognizes a novel protein sequence motif within N-CoR.
RARs and RXRs function as heterodimers that bind to response elements in the promoters of target genes to regulate RA dependent transcription.
Decreased growth factor and growth factor receptor expression has been proposed as a potential growth inhibitory mechanism [ 14 ] . Additionally, RA mediated inhibition of AP-1 activity is believed to be important in cellular growth control by this ligand [ 13 ] . AP-1 inhibition via direct interaction between RARs and AP-1 proteins has been proposed [ 16 ] . RA inhibition of jun N-terminal kinase was shown to prevent c-jun phosphorylation, resulting in decreased AP-1 activity [ 17 ] . Competition between RAR and AP-1 for limiting amounts of the nuclear receptor coactivator CBP may also account for decreases in AP-1 transcriptional activity [ 5 ] . In the present study we have described a new mechanism by which RA can inhibit cellular proliferation.
It is also possible that TAF II 135 expression modulates the activity of transcription factors in addition to the RARs leading to the appearance of this novel cell type.
Generally, NR transcriptional activity is dictated by the balance between coactivator and corepressor recruitment, and one of the most important factors that influences this balance is the absence or presence of agonist ligands (reviewed in [ 4 ] ). Unliganded NRs such as thyroid (TRs) and retinoid receptors (RARs) bind corepressors, and ligand promotes release of corepressor and subsequent binding of coactivators.
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