Words similar to rars
Example sentences for: rars
How can you use “rars” in a sentence? Here are some example sentences to help you improve your vocabulary:
It is also possible that TAF II 135 expression modulates the activity of transcription factors in addition to the RARs leading to the appearance of this novel cell type.
Decreased growth factor and growth factor receptor expression has been proposed as a potential growth inhibitory mechanism [ 14 ] . Additionally, RA mediated inhibition of AP-1 activity is believed to be important in cellular growth control by this ligand [ 13 ] . AP-1 inhibition via direct interaction between RARs and AP-1 proteins has been proposed [ 16 ] . RA inhibition of jun N-terminal kinase was shown to prevent c-jun phosphorylation, resulting in decreased AP-1 activity [ 17 ] . Competition between RAR and AP-1 for limiting amounts of the nuclear receptor coactivator CBP may also account for decreases in AP-1 transcriptional activity [ 5 ] . In the present study we have described a new mechanism by which RA can inhibit cellular proliferation.
These findings suggest that tumorigenic transformation and perhaps neoplasia of prostate epithelial cells are associated with abnormal expression and androgen regulation of RARs.
Generally, NR transcriptional activity is dictated by the balance between coactivator and corepressor recruitment, and one of the most important factors that influences this balance is the absence or presence of agonist ligands (reviewed in [ 4 ] ). Unliganded NRs such as thyroid (TRs) and retinoid receptors (RARs) bind corepressors, and ligand promotes release of corepressor and subsequent binding of coactivators.
The RARα amino terminus is not known to interact with CBP or its associated factor PCAF [ 5 18 ] . Additionally, RARs bind to the interaction domains of repressor proteins such as NCoR via region D of the receptor rather than the amino terminus [ 4 ] . Despite the lack of obvious interaction of the RAR amino terminus with nuclear receptor cofactors, the S77A mutation may alter the three dimensional structure of the receptor.
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