Example sentences for: rarγ

How can you use “rarγ” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • II 135 in extracts where ubiquitination of RARγ2 can be detected (our unpublished data), at early times we do observe a significant shift in the electrophoretic mobility of TAF II 135 which may correspond to a polyubiquitinated intermediate While the molecular events involved in degradation of transcription factors are in general poorly understood, it is noteworthy that both NRs and TBP have been reported to interact with the proteasome component SUG1 [ [ 60 61 ] ] which may act to target these proteins for degradation.

  • A lesser delay in degradation of RARγ2 in line B was also observed.

  • In F9 cells, RARγ2 plays a key role in primitive endoderm differentiation [ [ 58 59 ] ]. 48 hours after addition of T-RA degradation of this protein begins such that by 3-4 days most of the protein is depleted [ 42].

  • Again, the phenotype of these cells is not the same as that of the RXRα -/-RARγ -/-cells where none of these events take place.

  • We show here that T-RA-induced primitive endoderm differentiation is impaired in cell lines constitutively expressing ectopic TAF II 135(372-1083) as judged from, retarded targeted degradation of RARγ2, cell morphology, growth inhibition, apoptotic response, and induction of the RARβ2 marker gene.


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