Example sentences for: phosphorylation

How can you use “phosphorylation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Pretreating the cells with PTX (100 ng/ml), or the specific δ-OR antagonist, naltrindole (10 μM), completely blocked the DSEET-induced increase in ERK phosphorylation (Figure 1b).

  • Heat pretreatment did not significantly alter [cAMP] and [cGMP] levels despite significantly increased ser 16-HSP20 phosphorylation and suppressed force.

  • Although Cdc5 activity (1) is necessary to free nucleolar Cdc14 in late mitosis, (2) can elicit ectopic release of Cdc14 in pre-anaphase cells when overproduced, (3) regulates the phosphorylation state of Net1 during anaphase, and (4) can disassemble native and recombinant RENT complexes in vitro by phosphorylating Net1, a combination of in vivo and in vitro phosphosite mapping and mutagenesis experiments suggest that Cdc5 mediates exit from mitosis primarily by phosphorylating targets other than Net1.

  • In response to receptor activation, Syk becomes non-covalently associated with the BCR through tandem SH2 domains located in the amino terminal half of the protein [ 44 ] . Following engagement of the BCR, phosphorylation of specific tyrosine residues in immunoreceptor tyrosine-based activation motifs (ITAMs) found within the cytoplasmic tails of CD79a and CD79b provides docking sites for Syk localization [ 45 46 47 ] . The ability of phosphorylated ITAM peptides to selectively enhance Syk kinase activity in vitro suggests that recruitment of Syk to the receptor complex may serve to activate the kinase, in part, through allosteric changes in the structure of the Syk protein [ 44 48 49 ] . Upon activation, Syk and the receptor complex become localized in detergent-resistant cholesterol-rich membrane microdomains (lipid rafts), resulting in the segregation of the BCR complex from other membrane components [ 50 ] .

  • This TGFβ 1 -induced expression profile was not affected by preincubation of SMAD4 deleted BxPC-3 cells with a TGFβ 1 -RII blocking antibody, which was able to completely block TGFβ 1 -induced SMAD2/3 phosphorylation, thus demonstrating the independence of the TGFβ 1 -signaling from the known SMAD pathway in BxPC-3 cells.


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