Example sentences for: phosphorylation

How can you use “phosphorylation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Phorbol esters are often used as activators of protein kinase C (PKC) to investigate the role of the kinase in cellular functions [ 1 ] . Pancreatic β-cells possess α, β1, δ and ε PKC isotypes [ 2 ] , and activation of PKC is known to synergize with glucose stimulation in insulin secretion [ 3 4 5 ] . PKC, via protein phosphorylation seems to facilitate exocytosis of insulin granules [ 6 7 8 ] . In glucose-stimulated insulin secretion, ATP-sensitive K +channels (K ATP (SUR1, Kir6.

  • In particular PPK and PPNK can utilize Poly(P) to synthesize nucleoside polyphosphates, while PPK along with adenylate kinase can carry out polyphosphate-dependent phosphorylation AMP [ 33 34 35 ] . Hence, it is likely that the CYTH domain proteins participate directly in this biochemical network along with these proteins.

  • By contrast, a deletion of twelve residues of the human alpha-2A receptor (293-304) which includes the EESSSSE motif did not appear to prevent agonist-induced down-regulation [ 26 ] . Thus a phosphorylation pathway may not be involved in agonist-induced down-regulation of the alpha-2A adrenergic receptor.

  • Most frequently, poor MHCII inducibility in response to IFNg has been attributed to alterations in the IFNg signalling pathway and epigenetic silencing of gene expression (reviewed in Ref [ 13 ] ). The cascade of IFNg signalling events leading to transcription activation of MHCII genes has been characterized in great detail (reviewed in Ref [ 30 ] ). Binding of IFNg to its receptor results in JAK-mediated phosphorylation of STAT1 on Tyrosine 701.

  • GSK3β-dependent phosphorylation of p53 at serine 33 may be part of other p53-regulatory pathways, such as oncogene activation or apoptosis, which are not directly activated by DNA-damage.


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