Example sentences for: phosphorylates

How can you use “phosphorylates” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The now-activated JAK2 phosphorylates STAT3, which forms homodimers, can cross the nuclear membrane and function as a transcription factor, inducing various genes including genes involved in the cellular transformation process [ 15 ] .

  • TGFβ signals through a heteromeric receptor complex of type II and type I receptor serine-threonine kinases, which activates the downstream Smad signal transduction pathway [ 7 ] . After TGFβ binding to the receptor complex, the TGFβ type II receptor kinase phosphorylates TGFβ type I receptor which inititates the downstream response by phosphorylating receptor-regulated Smads (R-Smads), such as Smad2 and Smad3.

  • The product of the Ataxia Telangiectasia gene, the ATM protein kinase [ 9], directly phosphorylates serine 15 of the p53 protein in response to Ionizing Radiation [ 10, 11].

  • When recruited to stalled transcription complexes, P-TEFb phosphorylates serines at position 2 in the CTD [8], the Spt5 subunit of DSIF [9], and the RD subunit of NELF [10].

  • In the absence of a BR signal, BIN2 phosphorylates the transcription factors BES1 and BZR1, targeting them for proteolysis by the 26S proteasome.


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