Example sentences for: phosphorylates

How can you use “phosphorylates” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • GSK3β phosphorylates several transcription factors, including NFATc and HSF1 [ 24, 25, 26, 27].

  • In response to DNA damage induced by ionizing radiation or chemical agents such as cisplatin, ATM kinase is activated and phosphorylates a number of downstream regulatory proteins important for cell cycle arrest, growth control, apoptosis and DNA repair [ 25 26 27 28 ] . AT patients are known to be predisposed to a variety of cancers, and the fibroblasts of AT patients are hypersensitive to ionizing radiation [ 29 ] . Although many reports showed the association of ATM mutation with risk of a number of different human malignancies, including prostate cancer, breast cancer, ovarian cancer, B-cell chronic lymphocytic leukemia and mantle cell lymphoma, the underlying molecular mechanism by which ATM gene causes these changes are not well understood [ 30 31 32 33 34 35 ] . There is so far no study showing the association of ATM gene with any solid tumor.

  • Tem1 recruits Cdc15 to the spindle pole body, which in turn recruits and phosphorylates the Dbf2/Mob1 protein kinase complex, thereby switching it on [ 2 14 15 16 17 ] . The Tem1-signaling pathway eventually triggers disassembly of the RENT complex, enabling the release of Cdc14 (and a portion of Sir2) from Net1.

  • P-TEFb phosphorylates the carboxy-terminal domain of the RNA polymerase II complex [ 12], facilitating transcription elongation.

  • In addition, ATM phosphorylates and activates chk2 kinase [ 12].


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