Words similar to phosphorylates
Example sentences for: phosphorylates
How can you use “phosphorylates” in a sentence? Here are some example sentences to help you improve your vocabulary:
In the absence of a Wnt signal, GSK3 phosphorylates β-catenin, which then becomes targeted for degradation [ 6 ] . The binding of Wnt to its receptors initiates a cascade of events that inhibit GSK3 and ultimately prevent degradation of β-catenin.
In yeast and mammalian cells, GCN2 is a protein that senses amino acid starvation and brings about altered cell physiology in response to such starvation [ 24 25 ] . GCN2 is a protein kinase that phosphorylates the α subunit of the translation initiation factor eIF2 [ 26 ] . The GCN2 protein from yeasts, Drosophila , and mammals is composed of three domains: a pseudokinase domain that may function as a regulatory domain, a kinase domain, and a HisRS domain that shares significant similarity to histidyl-tRNA synthetases [ 27 28 29 30 ] . Studies of yeast GCN2 revealed that the HisRS domain binds uncharged tRNAs that accumulate when cells are starved for amino acids [ 31 32 ] . As a result the kinase domain is activated and phosphorylates eIF2α at Ser51.
Tem1 recruits Cdc15 to the spindle pole body, which in turn recruits and phosphorylates the Dbf2/Mob1 protein kinase complex, thereby switching it on [ 2 14 15 16 17 ] . The Tem1-signaling pathway eventually triggers disassembly of the RENT complex, enabling the release of Cdc14 (and a portion of Sir2) from Net1.
An Arabidopsis CPK phosphorylates tonoplast intrinsic protein, α-TIP, a putative water-channel protein [ 76].
These results indicate that IfkA is normally active from about 1 hour to about 7 hours after starvation and normally phosphorylates eIF2α during this time period (however, we have no direct data that demonstrates IfkA phosphorylates eIF2α).
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