Words similar to phosphorylating
Example sentences for: phosphorylating
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5 bp from the dmsABC P1 promoter as also established by DNase I footprinting analyses [ 7 8 ] . The presence of nitrate, a preferred alternative electron acceptor, elicits a 10-fold repression of dmsABC expression via the NarXLQP two-component regulatory system [ 4 9 10 ] . Nitrate is detected by either of the two sensor-transmitter proteins, NarX or NarQ, which then activate the DNA binding response-regulatory protein NarL, by phosphorylating an aspartate residue located at position 59.
TGFβ signals through a heteromeric receptor complex of type II and type I receptor serine-threonine kinases, which activates the downstream Smad signal transduction pathway [ 7 ] . After TGFβ binding to the receptor complex, the TGFβ type II receptor kinase phosphorylates TGFβ type I receptor which inititates the downstream response by phosphorylating receptor-regulated Smads (R-Smads), such as Smad2 and Smad3.
Although the overall rate of initiation of translation is reduced by eIF2α phosphorylation, the translation of some specific mRNAs is greatly enhanced under these conditions [ 24 25 ] . The characteristic feature of mRNAs whose translation is enhanced by GCN2 phosphorylating eIF2α are several upstream open reading frames (uORF) within the 5' untranslated region (5'UTR) of the mRNAs.
Upon initiation of chromosome segregation, Cdc5 promotes the transient 'Cdc14 early anaphase release' [ 26 ] . Our data suggest that Cdc5 can promote FEAR by directly phosphorylating Net1 as well as other yet-to-be-identified FEAR factors.
Although Cdc5 activity (1) is necessary to free nucleolar Cdc14 in late mitosis, (2) can elicit ectopic release of Cdc14 in pre-anaphase cells when overproduced, (3) regulates the phosphorylation state of Net1 during anaphase, and (4) can disassemble native and recombinant RENT complexes in vitro by phosphorylating Net1, a combination of in vivo and in vitro phosphosite mapping and mutagenesis experiments suggest that Cdc5 mediates exit from mitosis primarily by phosphorylating targets other than Net1.
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