Example sentences for: phosphorothioate

How can you use “phosphorothioate” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The phosphorothioate analogs, 5b and 6b, bound approximately 10 and 75 times better to Fhit than 1 . Thus, conservation of bond-lengths between adenylate moieties of 1 , 5 and 6 is conducive to binding Fhit.

  • The contribution of particular P-chiral phosphorothioate stereoisomers to inhibition has not been examined.

  • Phosphorodithioate 6c was a less effective inhibitor ( K i = 8600 nM, not shown in Tables) than corresponding phosphate 6a and phosphorothioate 6b and, as demonstrated in Tables 1and 2, the phosphorothioate congener of every compound made as a phosphate and a phosphorothioate had a lower K i value.

  • Because phosphorothioate analogs of 5 and 6 were better inhibitors than the corresponding phosphates, phosphorodithioate analog 6c was prepared together with five additional compounds as phosphates and phosphorothioates.

  • Compound 12b, which one would expect to bind Fhit with bulky phosphorothioate and phosphorothioadenosyl groups interfering with putative effector binding, may consequently prove to be antagonistic to Fhit function.

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