Words similar to phosphorothioate

Example sentences for: phosphorothioate

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Phosphorodithioate 6c was a less effective inhibitor ( K i = 8600 nM, not shown in Tables) than corresponding phosphate 6a and phosphorothioate 6b and, as demonstrated in Tables 1and 2, the phosphorothioate congener of every compound made as a phosphate and a phosphorothioate had a lower K i value.
Because phosphorothioate analogs of 5 and 6 were better inhibitors than the corresponding phosphates, phosphorodithioate analog 6c was prepared together with five additional compounds as phosphates and phosphorothioates.
Phosphorothioate substitution implicates the A-4 phosphate in interaction with protein, but since LysA43 also forms a contact here a possible involvement of LysA61 is obscured.
Earlier, Blackburn and co-workers made "supercharged" methane-trisphosphonic acid AppppA analogs containing a central carbon from which three adenylate or phosphate moieties are bonded [ 15 ] . In work presented here, tripodal inhibitors 15a and 17a showed, respectively, micromolar and submicromolar efficacies while the phosphorothioate counterparts 15b and 17b showed 100 nM efficacy.
The phosphorothioate analogs, 5b and 6b, bound approximately 10 and 75 times better to Fhit than 1 . Thus, conservation of bond-lengths between adenylate moieties of 1 , 5 and 6 is conducive to binding Fhit.