Example sentences for: phosphorothioadenosyl

How can you use “phosphorothioadenosyl” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • While compound 14b, containing two phosphorothioylated branches without adenosine, was barely a submicromolar inhibitor, compounds 12b and 13b, which contain respectively three and four CH 2 -phosphorothioadenosyl groups bonded to the central carbon were 40 nM and 65 nM inhibitors.

  • A series of compounds 2-6 were synthesized and evaluated for Fhit inhibition that link two 5'- O -phosphorothioadenosyl or AMP groups with five reagents ranging in size from ethylene glycol to meso -erythritol.

  • On the basis of observations [ 12 13 ] discussed above, one would expect AppppA with two phosphorothioadenosyl substituents to be a slow substrate with a relatively low K m . However, carbon in place of the β phosphorus (for example in 6b ) would make the leaving group the alkoxide - OCH 2 -CH(OH)-CH 2 O-phosphorothioadenosyl rather than α-thio ATP.

  • Thus, while the simplest compound 6b was initially rendered less inhibitory by modification because its central hydroxyl was important for inhibition, addition of one or two CH 2 -phosphorothioadenosyl groups restored inhibition.

  • We presume that compounds 6b , 12b and 13b with 2, 3 or 4 identical CH 2 -phosphorothioadenosyl groups can present a manganese bound 6b -like complex to Fhit in a similar manner.


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