Words similar to phosphorothioadenosyl

Example sentences for: phosphorothioadenosyl

How can you use “phosphorothioadenosyl” in a sentence? Here are some example sentences to help you improve your vocabulary:

While compound 14b, containing two phosphorothioylated branches without adenosine, was barely a submicromolar inhibitor, compounds 12b and 13b, which contain respectively three and four CH 2 -phosphorothioadenosyl groups bonded to the central carbon were 40 nM and 65 nM inhibitors.
A series of compounds 2-6 were synthesized and evaluated for Fhit inhibition that link two 5'- O -phosphorothioadenosyl or AMP groups with five reagents ranging in size from ethylene glycol to meso -erythritol.
Compound 12b, which one would expect to bind Fhit with bulky phosphorothioate and phosphorothioadenosyl groups interfering with putative effector binding, may consequently prove to be antagonistic to Fhit function.
We presume that compounds 6b , 12b and 13b with 2, 3 or 4 identical CH 2 -phosphorothioadenosyl groups can present a manganese bound 6b -like complex to Fhit in a similar manner.
Thus, while the simplest compound 6b was initially rendered less inhibitory by modification because its central hydroxyl was important for inhibition, addition of one or two CH 2 -phosphorothioadenosyl groups restored inhibition.