Example sentences for: phosphatases

How can you use “phosphatases” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It is to be mentioned that among all the Ser/Thr phosphatases, PP1 has been subjected to the most extensive structure-function analysis [ 19 20 21 22 23 24 25 26 ] . In fact, it was one of the first phosphatases for which the three-dimensional structure was solved [ 26 27 ] . A representative alignment in Fig.

  • This GPCR-mediated regulation of ion channels also depends on the coordination and parallel regulation of protein tyrosine kinase and protein tyrosine phosphatase activities [ 24 ] . GPCRs can also interact with the growing family of PDZ domain-containing proteins [ 25 ] . All of these relationships are reflected in our study by the strong correlation between 7 transmembrane receptors (rhodopsin family) (PF00001), protein kinases (PF00069), protein tyrosine phosphatases (PF00102), ion transport proteins (PF00520), and PDZ domain proteins (PF00595).

  • Under conditions favoring proliferation, the phosphorylation of pRB via cyclin-dependent kinases (CDKs) in mid-to-late G 1 phase results in liberation of E2F and other pRB-bound transcription factors, which then activate the transcription of S-phase genes [ 19 ] . In late M phase, pRB returns to its growth suppressive, hypophosphorylated form due to the action of a pRB-directed protein phosphatase belonging to the type 1 class of serine/threonine protein phosphatases [ 11 20 21 ] .

  • Budding yeast lacking PPT1 do not exhibit obvious growth defects or detectable phenotypes [ 2 ] . Disruption of PPT1 together with one of the other known phosphatases in budding yeast also reveals no obvious phenotype [ 23 ] . Thus, if Ppt1p has an essential function in S. cerevisiae , more than one other phosphatase can also carry out this role.

  • First, PfPP5 contained the catalytic core found in all Ser/Thr phosphatases of the PPP family, including the signature motifs such as GDXHGQ, GDFVDRG, RGNHE, HGLL, and SAPNYCD, to name a few [ 22 23 ] . Site-directed mutagenesis and structural studies in PP 1 and PPλ have previously established the roles of specific amino acid residues in these domains in the various aspects of catalysis, such as metal ion binding, phosphate recognition, and co-ordination of water molecules [ 24 25 26 ] .

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