Example sentences for: phosphatases

How can you use “phosphatases” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To identify new Ser/Thr phosphatases of Pf, we have recently undertaken a PCR-based approach.

  • Finally, it has been shown that affinity resins containing immobilized microcystin specifically bind toxin-sensitive phosphatases such as PP1 and PP2A [ 31 ] . Thus, we passed soluble cytosolic Pf extract through microcystin-Sepharose, and the bound proteins were analyzed on SDS-PAGE followed by immunoblot using the anti-PP1 antibody.

  • The SAPNYC motif of PPP enzymes is essential for OA-binding, and is found in all OA-sensitive phosphatases including PP1, PP2A, and PP5 [ [ 25 27 28 ] , and references therein].

  • The dephosphorylation of phosphoproteins is universally catalyzed by protein phosphatases that are classified into two major functional groups, protein tyrosine phosphatase (PTP) and protein serine/threonine phosphatase (PP) although enzymes with various degrees of dual-specificity are also encountered [ 1 2 3 4 5 ] . The majority of Ser/Thr phosphatases belong to three classical groups, namely PP1, PP2A, and PP2B (calcineurin), and possess similar primary structures in their catalytic cores [ 2 3 6 ] . PP1, in particular, exhibits an extremely high degree of sequence conservation through evolution, and its orthologs and isoforms are found in all eukaryotic cells [ 6 7 ] . In various organisms, PP1 regulates such diverse cellular processes as cell cycle progression, protein synthesis, carbohydrate metabolism, transcription, and neuronal signaling [ 3 7 ] , underscoring its profound importance in biology.

  • When these inserts were omitted from the alignment, the rest of the sequence showed significant similarity with PP1 phosphatases [ 12 ] . Clearly, further studies are needed to identify the PPα protein and characterize its potentially interesting identity.


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