Words similar to phorbol
Example sentences for: phorbol
How can you use “phorbol” in a sentence? Here are some example sentences to help you improve your vocabulary:
Similar short-time activation of HUVEC with phorbol myristate acetate (PMA) (1 μg/mL), human thrombin receptor activating peptide (TRAP) 1-50 μmol/L, human thrombin (THR) 0.1-10 NIH Unit/mL, human tissue plasminogen activator (TPA) 3.5 kU/mL or human angiotensin II (AGTII) 1 μmol/L did not cause any significant increase in MP-release (Fig.
LPS stimulation of macrophages is known to involve the activation of protein phosphorylation by kinases as well as the activation of nuclear transcription factors such as NF-kappaB [ 10 11 12 13 ] . The activation of protein kinase C (PKC) by diacylglycerol is also a key event in LPS macrophage activation [ 8 ] . In vitro experiments have shown that the secretion of TNF-alpha and IL-1-beta by LPS-stimulated monocytes is dependent upon PKC activation [ 13 14 ] . In this study, we also determined if phorbol myristate acetate (PMA) activation of PKC also enhanced CEES toxicity.
1ACh, acetylcholine; ARF, ADP-ribosylation factor; DAG, diacylglycerol; G3PDH, glyceraldehyde 3-phosphate dehydrogenase; MAChR, muscarinic acetylcholine receptor; PA, phosphatidic acid; PC, phosphatidylcholine; PIP 2 , phosphatidylinositol 4, 5-bisphosphate; PKC, protein kinase C; PLD, phospholipase D; PMA, phorbol 12-myristate 13-acetate; PP, phosphatidylpropanol; ROS, reactive oxygen species; TLC, thin layer chromatography.
[ 36 ] ). It has been shown that treatment of cells with phorbol esters leads to accumulation of phosphorylated H3 histones [ 37 ] . Therefore, it seems possible that in LS1034 cells PMA could enhance transcriptional activity of chromatin at promoters of MHCII and/or CIITA genes.
The discovery of novel "non-kinase" phorbol ester receptors challenges the use of phorbol esters as selective PKC activators [ 24 ] . Therefore, we were interested in whether a member of the PKC family mediated the effect of PMA in LS1034 cells or whether some other proteins could also be involved.
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