Words similar to phorbol

Example sentences for: phorbol

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There are two possible explanations for the PKC-independent activation of K ATP by phorbol esters: 1) phorbol esters may increase K ATP activity in an intracellular ATP-independent manner and 2) phorbol esters may reduce sensitivity of K ATP to ATP.
Second, the non-PKC-stimulating phorbol ester, 4α-PDD, mimicked the effect of PMA (Fig.
Phorbol 12-myristate 13-acetate (PMA), 4a-phorbol 12,13-didecanoate (4a-PDD), bisindolylmaleimide (BIM) and NaCN were purchased from Sigma.
Other chemicals used were phorbol 12-myristate 13-acetate, dimethyl sulfoxide, ethanol, propidium iodide and saponin (all from Sigma).
In addition, other recent studies have shown that the membrane phospholipid phosohatidylinositol-4,5-bis-phosphate (PIP 2 ) reduces sensitivity of K ATP to ATP, and therefore, activates K ATP [ 32 33 34 ] . To our knowledge, this is the first report of regulation of K ATP activity by phorbol ester in rat β-cells.