Words similar to phorbol
Example sentences for: phorbol
How can you use “phorbol” in a sentence? Here are some example sentences to help you improve your vocabulary:
phorbol 12-myristate 13-acetate PMA
It has been established that, to achieve its maximal transcriptional activity, STAT1 must be phosphorylated on both Tyr701 and Ser727 [ 32 ] . Phosphorylation of STAT1 on Ser727 occurs in response to LPS, UV irradiation and other agents that activate the p38MAPK pathway [ 33 ] . As phorbol esters can also stimulate the MAPK cascade through activation of PKC [ 34 ] , it is tempting to speculate that combined treatment of cells with PMA and IFNg could increase the pool of STAT1 molecules phosphorylated on both Tyr701 and Ser727.
Phorbol esters are often used as activators of protein kinase C (PKC) to investigate the role of the kinase in cellular functions [ 1 ] . Pancreatic β-cells possess α, β1, δ and ε PKC isotypes [ 2 ] , and activation of PKC is known to synergize with glucose stimulation in insulin secretion [ 3 4 5 ] . PKC, via protein phosphorylation seems to facilitate exocytosis of insulin granules [ 6 7 8 ] . In glucose-stimulated insulin secretion, ATP-sensitive K +channels (K ATP (SUR1, Kir6.
AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; DMEM, Dulbecco's modified Eagle medium; FBS, fetal bovine serum certified; FCC, ferricytochrome c type III; HBSS, Hank's balanced salt solution; LPS, lipopolysaccharide; MMP-9, matrix metalloproteinase-9; O 2 -, superoxide; P, penicillin; PBS, phosphate buffered saline; PMA, phorbol 12-myristate 13-acetate ; RT-PCR, reverse transcriptase polymerase chain reaction; S, streptomycin; SOD, superoxide dismutase; TNF-α, tumor necrosis factor.
It is not clear at present whether ADP concentrations are changed by the phorbol ester.
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