Words similar to phorbol
Example sentences for: phorbol
How can you use “phorbol” in a sentence? Here are some example sentences to help you improve your vocabulary:
It is not clear at present whether ADP concentrations are changed by the phorbol ester.
It is known that during clonal selection in the thymus, immature CD4, CD8 double positive cells develop into single positive CD4 or CD8 cells according to the relative affinity of their TCR to class II or class I molecules respectively [ 5 6 ] . These immature T-cells are selected in the thymic epithelium on the basis of their TCR interaction with either class I or class II MHC molecules [ 7 8 ] , thus generating two mutually exclusive subpopulations that are characterized by the expression of either CD4 or CD8 glycoproteins [ 9 ] . Earlier studies in the murine system have demonstrated that PMA and cAMP can modulate the expression CD4 and CD8 on developing thymocytes [ 10 11 12 13 ] . In keeping with these findings, ex vivo experiments with human thymocytes previously reported by our group, revealed that while phorbol esters can coordinately regulate the transcription of α and β TCR during intrathymic T cell differentiation [ 14 ] , cAMP selectively affected the transcription of the α and δ-TCR [ 15 16 ] . Together the murine data and our own findings support the hypothesis that in humans, TCR expression and CD4, CD8 commitment and selection may be regulated by the same signal-transduction pathways.
Phorbol esters are often used as activators of PKC to investigate the role of the kinase in cellular functions [ 1 ] . Accumulating lines of evidence indicates that PMA plays a complex role in regulation of cellular function, including PKC-dependent [ 18 19 20 ] and PKC-independent ways [ 23 24 21 ] . In the present results, PMA inhibited slow membrane depolarization and action potentials in response to glucose stimulation (Fig.
Effect of phorbol ester on lysosomal pH
[ 12 ] . They found that phorbol dibutyrate induced phosphorylation in the C terminal region of HSP20 based on tryptic digest analysis.
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