Example sentences for: phosphatidylinositol-

How can you use “phosphatidylinositol-” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • PI-3Kinase activity is acutely regulated and a number of isoforms have been cloned that are activated in response to various stimuli [ 4 ] . The major phosphatidylinositol-3-phosphate phosphatase in cells is the tumor suppressor PTEN [ 5 6 ] . This protein has a tonic inhibitory effect on PI-3Kinase signaling by reversing the 3'-phosphorylation.

  • PI and PI3P (phosphatidylinositol-3-phosphate), presented in PS-based vesicles, appeared to stimulate slightly the proteolysis of Boi1-PH, but did so to a much lesser extent than did PIP 2 (Fig.

  • Phosphatidylcholine, phosphatidylinositol, and phosphatidylserine were from Avanti Polar Lipids (Alabaster, AL); phosphatidylinositol-4,5-bisphosphate and phosphatidylinositol-4-phosphate were from Calbiochem (San Diego, CA); and phosphatidylinositol-3-phosphate was from Matreya, Inc. (Pleasant Gap, PA).

  • Selected transcripts identified by microarray analysis, including β-actin, spectrin and phosphatidylinositol-4-kinase (PI4K), were subsequently confirmed by semi-quantitative RT-PCR (Fig.

  • Spectrin and protein 4.1 form a complex with actin filaments [ 17 26 ] that may be important in signaling in additional to forming a physical link between the cytoskeletal network and the cell membrane [ 27 ] . Furthermore, PI4K activity has been shown to associate with the actin cytoskeleton by biochemical detergent extraction [ 28 ] and is thought to specifically localize with α3β1 integrin [ 29 ] . PI4K catalyzes the production of phosphatidylinositol-4-phosphate, an intermediate in multiple phosphatidylinositol signaling pathways which itself can interact with actin binding proteins to regulate microfilament polymerization [ 30 ] . Our work now suggests that the mRNAs of these proteins are all positioned in close association with the actin cytoskeleton to permit efficient localization of their protein products.


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