Words similar to phosphatidylinositol
Example sentences for: phosphatidylinositol
How can you use “phosphatidylinositol” in a sentence? Here are some example sentences to help you improve your vocabulary:
Insulin transduces its cellular signal in most cell types via two signaling pathways, i.e., the p44/42 mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol 3-kinase (PI 3-kinase) pathway [ 8 ] . Insulin initially binds to the insulin receptor causing autophosphorylation of the β-subunit of the receptor [ 8 ] . The protein kinase domain of the β-subunit then phosphorylates tyrosine residues in insulin receptor substrate (IRS)-1, IRS-2, IRS-3, or Shc, which then activates the p44/42 MAPK signaling cascade [ 8 ] . PD98059 is a cell permeable, non-competitive, reversible inhibitor of MAPK/extracellular signal-regulated kinase kinase (MEK), a protein kinase upstream of p44/42 MAPK [ 9 ] . Tyrosine phosphorylated IRS also activates the PI 3-kinase pathway [ 8 10 ] . There are at least three, well-characterized inhibitors of the PI 3-kinase pathway, i.e., wortmannin, LY294002, and rapamycin [ 11 12 13 ] . Wortmannin and LY294002 block the activation of PI 3-kinase itself [ 11 12 ] , while rapamycin prevents the phosphorylation of a downstream effector in the pathway, p70 S6 kinase [ 13 ] .
asbt, apical sodium/bile acid cotransporter; GCA, glycocholic acid; GCDCA, glycochenodeoxycholic acid; HBAB, human bile acid binder; LDH, lactate dehydrogenase; PI3K, phosphatidylinositol 3-kinase; TCA, taurocholic acid, TCDCA, taurochenodeoxycholic acid
ANOVA = analysis of variance; Erk= extracellular signal-regulated kinase; IC 50 = half-maximal inhibition; IRS = insulin receptor substrate; LDH = lactate dehydrogenase; MAPK = mitogen-activated protein kinase; MEK = MAPK/extracellular signal-regulated kinase kinase; mTOR = mammalian target of rapamycin; PBS = phosphate-buffered saline; PI 3-kinase = phosphatidylinositol 3-kinase; RDS = respiratory distress syndrome; SD = standard deviation of the mean; SE = standard error of the mean; SP = surfactant protein; TPA = 12-
fwd encodes a 1-phosphatidylinositol 4-kinase (PI 4-kinase) that regulates actin organization and ring canal formation during germline cytokinesis [ 40].
PI 3-kinase induces Btk membrane targeting by generating phosphatidylinositol 3,4,5-trisphosphate (PIP3) to which the PH domain of Btk binds.
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