Words similar to phosphatidylinositol
Example sentences for: phosphatidylinositol
How can you use “phosphatidylinositol” in a sentence? Here are some example sentences to help you improve your vocabulary:
24 cells as described previously [ 44 ] . To prepare lipid suspension, phosphatidylserine and phosphatidylinositol (1:1) were sonicated in 25 mM 3-(N-morpholino)propanesulfonic acid (MOPS; pH 7.0), 1 mM EGTA, 1 mM Na 3 VO 4 . Cell extracts were assayed in 25 mM MOPS (pH 7.5), 5 mM MgCl 2 , 1 mM EGTA, 1 mM Na 3 VO 4 , 130 μM ATP, 20 μCi [ 32P]-ATP (3000 Ci/mmol) and 0.2 mg/ml sonicated lipids.
First, PTEN's protein phosphatase activity is able to down-regulate focal adhesion kinase (FAK) phosphorylation, which leads to the inactivation of the Ras/MAP kinase pathway [ 19 20 21 ] . Second, its lipid phosphatase activity targets the second messenger phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P 3 ] and thereby blocks activation of the protein kinase B (PKB/Akt) pathway [ 11 18 22 23 24 ] . Whereas both of the above pathways are intimately involved in the control of cell growth and survival, PTEN-regulated FAK activity further appears to impinge on cell adhesion, cell migration, and cell invasion [ 20 21 ] . It therefore emerges that the loss of PTEN activity may confer increased survival ability, proliferative potential, and invasive capacity on cells, and thereby may promote progression towards a more malignant phenotype.
PI 3-kinase induces Btk membrane targeting by generating phosphatidylinositol 3,4,5-trisphosphate (PIP3) to which the PH domain of Btk binds.
fwd encodes a phosphatidylinositol 4-kinase (PI 4-kinase) that converts phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PIP) [ 40].
1ACh, acetylcholine; ARF, ADP-ribosylation factor; DAG, diacylglycerol; G3PDH, glyceraldehyde 3-phosphate dehydrogenase; MAChR, muscarinic acetylcholine receptor; PA, phosphatidic acid; PC, phosphatidylcholine; PIP 2 , phosphatidylinositol 4, 5-bisphosphate; PKC, protein kinase C; PLD, phospholipase D; PMA, phorbol 12-myristate 13-acetate; PP, phosphatidylpropanol; ROS, reactive oxygen species; TLC, thin layer chromatography.
Loading...