Words similar to mitomycin
Example sentences for: mitomycin
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The results of cell culture and animal studies have shown that omega 3 polyunsaturated fatty acids (n-3 PUFAs) selectively killed cancer cells in vitro [ 1 ] . Furthermore, n-3 PUFAs incorporated into animal diets have reduced tumor growth rates in vivo [ 2 3 4 ] . The prevailing hypothesis for the reduction in tumor cell growth, in vitro or in vivo , by supplementing the diet with high levels of n-3 PUFAs has been that the incorporation of n-3 PUFAs into cell membranes of the tumor cells increased the susceptibility of the cells for lipid peroxidation and that the products of lipid peroxidation subsequently accumulated to cytostatic or cytotoxic levels [ 2 5 6 7 ] . It has also been reported that supplementing the diet of cancer xenograft bearing mice with n-3 PUFAs could increase the efficacy of edelfosine [ 8 ] , doxorubicin [ 9 ] , mitomycin [ 10 ] , cyclophosphomide and 5-fluorouracil [ 11 ] or irinotecan [ 12 ] against the tumor.
Treatment with mitomycin C did not affect the time course of wound closure of either the wild-type or SPARC-null cells (Fig.
The wound in a monolayer of wild-type fibroblasts cultured in the absence or presence of mitomycin C healed by 15 hours after wounding (Fig.
The wounded monolayers were incubated at 37°C in DMEM containing 10% FBS with or without mitomycin C (10 μg/ml, Sigma, St Louis, MO) to block mitosis.
The wound in a monolayer of SPARC-null fibroblasts, whether cultured in the presence of mitomycin C or in its absence, remained unrepaired at 15 hours, began to show slight closure at 24 hours and healed by 48 hours (Fig.
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