Words similar to mitosis
Example sentences for: mitosis
How can you use “mitosis” in a sentence? Here are some example sentences to help you improve your vocabulary:
By counteracting Cdk1-mediated phosphorylations, Cdc14 activates both Hct1/Cdh1, which targets Clb2 for degradation [ 3 4 5 ] , and Swi5, which turns on the transcription of Cdk1 inhibitor Sic1 [ 6 3 ] . Degradation of Clb2 and accumulation of Sic1 act in concert to eliminate mitotic Cdk activity, which is required for exit from mitosis [ 7 ] . Thus, elucidating how Cdc14 is regulated holds the key to understanding how cells exit mitosis.
During exit from mitosis, a TEM1/CDC15 -dependent signal frees Cdc14 from the nucleolus and allows it to promote inactivation of Clb/Cdc28 [ 15 17 19 ] . The fact that both Net1 and Cdc14 are directly involved in exit from mitosis validates the effectiveness of the tab screen and heightens the potential value of the uncharacterized tab mutants.
In the budding yeast Saccharomyces cerevisiae , the mitotic exit network (MEN) plays a pivotal role in driving cells from mitosis to G1.
Surprisingly, cdc5-1 cells grown at 25°C could exit mitosis despite persistent nucleolar localization of Cdc14, which may have been due to release of a small fraction of Cdc14 that was nevertheless sufficient to drive exit from mitosis in these cells.
Biochemical and cell biological experiments indicate that Net1 acts as part of a complex named RENT that tethers Cdc14 to the nucleolus and inhibits Cdc14 phosphatase activity, and that CDC15 and TEM1 are required for the release of Cdc14 from Net1 at the end of mitosis [ 15 16 17 43 ] . Consistent with this notion, both net1 tab 2-1(which encodes a mutant version of Net1 with presumably reduced affinity for Cdc14) and CDC14 TAB 6-1(which encodes a mutant version of Cdc14 with reduced affinity for Tab2/Net1) bypass cdc15Δ [ 15 18 ] . Both net1 tab 2-1and CDC14 TAB 6-1impinge directly on mitotic exit, suggesting that other TAB genes may encode physiological regulators and effectors of the Mitotic Exit Network.
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