Words similar to mitogens
Example sentences for: mitogens
How can you use “mitogens” in a sentence? Here are some example sentences to help you improve your vocabulary:
Numerous studies have shown that polypeptide growth factors such as insulin-like growth factors (IGFs) are mitogens for breast cancer cells [ 6 7 8 9 ] . The IGF-I and IGF-II signal through a common tyrosine kinase receptor, the insulin-like growth factor 1 receptor (IGF1R), and have mitogenic and cell survival actions that may promote tumor development.
3C) is a member of epidermal growth factor (EGF) family of mitogens [ 29 ] . Expression of epiregulin has been reported to be highest in placenta and in a subset of carcinoma cells.
Several lines of evidence indicate that NF-κB is constitutively activated in cancer cells, suggesting that it plays an important role in tumorigenesis [ 30 ] . Activated glucocorticoid receptors have been shown to repress NF-κB-mediated gene expression [ 31 ] , and to cause a significant reduction in nuclear levels of p65 protein, a subunit of NF-κB [ 31 ] . A variety of mitogens, cytokines, and reactive oxygen intermediates have been shown to rapidly cause the translocation of NF-κB to the nucleus [ 30 31 32 ] , and the ability of dexamethasone to interfere with this translocation is blocked by prior treatment with the glucocorticoid antagonist RU 486 [ 30 ] . Based on these findings, it is plausible to speculate that exposure to RU 486 may interfere with the function of endogenous glucocorticoids as regulators of cell cycle, allowing the initiation and progression of malignant transformation of liver cells.
Patients when received a concomitant therapy of TAC and SRL exhibited a significant inhibition of their lymphocytes when cultured with mitogens; PHA, ConA and anti-CD3, compared to the proliferation of lymphocytes obtained from when they were treated with TAC and MMF/Aza.
The response of BRCA1 mRNA and protein levels to mitogens and hormones in vitro suggests that BRCA1 may play a role in regulation of cell growth or maintenance [ 21].
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