Words similar to mitogenic
Example sentences for: mitogenic
How can you use “mitogenic” in a sentence? Here are some example sentences to help you improve your vocabulary:
There is most likely a large protein complex assembled at the SRE composed of regulated transcription factors, coactivators, and the basal transcriptional machinery, resulting in rapid transcription of the c-fos gene in response to mitogenic stimulation.
Numerous studies have shown that polypeptide growth factors such as insulin-like growth factors (IGFs) are mitogens for breast cancer cells [ 6 7 8 9 ] . The IGF-I and IGF-II signal through a common tyrosine kinase receptor, the insulin-like growth factor 1 receptor (IGF1R), and have mitogenic and cell survival actions that may promote tumor development.
The lack of aberrant neuronal proliferation in our mice suggests that differentiated neurons may not be as susceptible to the mitogenic effects of Wnt signaling as are neuroepithelial progenitor cells [ 22 ] .
Although several laboratories reported that crosslinking CD5 on the surface augments T cells signaling by inducing calcium flux and enhancing mitogenic response [ 14, 15, 16], recent studies using CD5-deficient mice indicate that CD5 may be more important as a negative modulator of TCR and BCR signal transduction [ 17, 18].
Infection of cultured podocytes with replication incompetent HIV-1 demonstrated that HIV-1 gene expression leads to the proliferation and dedifferentiation of the infected podocytes [ 6 7 8 ] , recapitulating the phenotypes observed in HIVAN specimens [ 9 10 ] . Similarly, renal expression of replication incompetent HIV-1 proviral transgenes in mice and rats produces a proliferative renal lesion that is indistiguisable both histopathologically and clinically from human HIVAN [ 11 12 13 14 ] . These observations raise the possibility that HIV-1 gene products may interact with mitogenic pathways in infected renal epithelium to cause aberrant cell-cycle engagement.
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