Words similar to mitogenic
Example sentences for: mitogenic
How can you use “mitogenic” in a sentence? Here are some example sentences to help you improve your vocabulary:
In addition, BMP-7 and -15, but not BMP-6 have stimulatory effects on GC DNA synthesis, indicating they may play a mitogenic role in follicle growth [ 8 12 13 ] . The importance of this finding is underscored by the fact that the control of GC proliferation is crucial for follicle dominance and atresia.
With the isolation of the lymphocyte-derived molecule responsible for T cell Growth Factor (TCGF) activity, which came to be known as interleukin 2 (IL-2) [ 9 10 ] , and discovery of IL-2 receptors (IL-2R) [ 11 ] , it could be shown that mitogenic lectins and specific antigens triggered an initial activation event, which was analogous to the activation of cell cycle "competence" by serum-stimulated fibroblasts, and resulted in transition from the G 0 to the G 1 phase of the cell cycle [ 12 13 ] . However, just as in serum-stimulated fibroblasts, this initial activation event did not result in lymphocyte proliferation.
Thus, although BRCA1 may not be regulated directly by hormones, the BRCA1 gene product may be involved in the regulation of hormone response pathways, and the present results may demonstrate that loss of BRCA1 may result in loss of inhibitory control of these mitogenic pathways.
The effects of PGs on cell proliferation and collagen production have been widely studied in different cell types [ 13 14 15 16 17 26 ] . TXA 2 has been studied extensively because of its apparent role in atherosclerosis, due to its prothrombotic and mitogenic activities on vascular smooth muscle cells [ 15 16 ] . These mitogenic effects are potentiated by growth factors [ 15 16 27 28 ] . In vascular smooth muscle cells TXA 2 stimulates synthesis of bFGF and increases the expression of the proto-oncogenes c-fos , c-myc , and egr-1 , which are associated with entry into the cell growth cycle [ 15 ] . In addition, TXA 2 increases proliferation of fibroblasts [ 13 ] and smooth muscle-like glomerular mesangial cells [ 14 ] .
eIF4E gene transcription is enhanced in response to mitogenic stimulation and may be mediated by c-myc [ 3 ] . Phosphorylation of eIF4E by the protein kinase Mnk1 increases its affinity for the cap, and thus increases cap-dependent initiation of translation [ 4 5 6 ] . An inhibitor of eIF4E, 4E binding protein (4EBP), is also regulated by phosphorylation.
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