Words similar to mitogenic
Example sentences for: mitogenic
How can you use “mitogenic” in a sentence? Here are some example sentences to help you improve your vocabulary:
With the isolation of the lymphocyte-derived molecule responsible for T cell Growth Factor (TCGF) activity, which came to be known as interleukin 2 (IL-2) [ 9 10 ] , and discovery of IL-2 receptors (IL-2R) [ 11 ] , it could be shown that mitogenic lectins and specific antigens triggered an initial activation event, which was analogous to the activation of cell cycle "competence" by serum-stimulated fibroblasts, and resulted in transition from the G 0 to the G 1 phase of the cell cycle [ 12 13 ] . However, just as in serum-stimulated fibroblasts, this initial activation event did not result in lymphocyte proliferation.
The precursor of heparin-binding EGF-like growth factor (proHB-EGF) is found on a wide variety of cell surfaces and is present in numerous tissue types [ 1 ] . Previously in our laboratory, we cloned the cDNA encoding proHB-EGF from monkey Vero cells and identified this cell-surface molecule as a receptor for diphtheria toxin (DT) [ 2 ] . The predicted amino acid sequence was shown to be identical to that of the cell surface-expressed precursor of human heparin-binding EGF-like growth factor (proHB-EGF) [ 3 4 ] . The derived amino acid sequence revealed a signal sequence (residues 1-23), an extracellular domain (residues 24-159), a transmembrane domain (residues 160-184), and a carboxyl terminal cytoplasmic domain (residues 185-208) [ 2 ] . Proteolytic processing of the proHB-EGF occurs on the cell surface and results in the release of mature HB-EGF (mHB-EGF) (residues 63-148) [ 5 ] . The mature/soluble HB-EGF is a member of the EGF family of growth factors that includes amphiregulin, epidermal growth factor, and transforming growth factor a [ 6 ] . Mature HB-EGF released from the cell surface is mitogenic and is able to bind to the EGF receptor [ 3 ] . Membrane-bound proHB-EGF has juxtacrine growth factor activity [ 7 ] and also acts as a DT receptor [ 2 8 ] .
c-fos is a member of the family of immediate early genes, and its transcription is transiently induced in response to mitogenic signals [ 1].
In addition, BMP-7 and -15, but not BMP-6 have stimulatory effects on GC DNA synthesis, indicating they may play a mitogenic role in follicle growth [ 8 12 13 ] . The importance of this finding is underscored by the fact that the control of GC proliferation is crucial for follicle dominance and atresia.
Interestingly, this synergy is only observed in response to mitogenic stimulation by Ras.
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