Example sentences for: mitochondrial

How can you use “mitochondrial” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • StAR plays a key role in the initial steps of steroidogenesis, because it is required for transport of cholesterol to the inner mitochondrial membrane where CYP11A1 resides and the first reaction in progesterone synthesis occurs [ 45 ] . cAMP is a well known second messenger in FSH- and LH-stimulated progesterone synthesis, and a key effect of the cAMP-dependent protein kinase in GC is transcriptional control of StAR [ 46 47 ] . Estradiol is recognized as a biological amplifier of basal, FSH- and cAMP-stimulated progesterone production in pig GC, with significant synergistic effects distal to the generation of cAMP at one or more steps in cholesterol transport and metabolism [ 48 ] . Our experimental results are thus consistent with 4-AP inhibition of GC progesterone output via drug effects on multiple interacting sites in the steroidogenic pathway.

  • Class Ib mitochondrial diseases arise from mutations in any of the 70-odd nuclear genes encoding protein subunits involved in oxidative phosphorylation [ 5].

  • Depending on the experimental conditions, treatment of RPE with H 2 O 2 can cause an alteration of cellular functions [ 6 7 ] or cell death [ 8 9 ] . Cytotoxic levels of H 2 O 2 can cause significant mitochondrial [ 10 ] and genomic [ 11 ] DNA damage in RPE simulating the features of programmed cell death [ 8 12 ] . Studies from other cell types indicate that early cellular events following H 2 O 2 treatment include morphological alterations and actin re-organization [ 13 ] . In addition, activation of the ERK (p42/44, Extracellular signal-Regulated Kinase) MAP kinases (Mitogen-Activated Protein kinases) can occur within minutes following cellular oxidative stress.

  • Inborn errors of mitochondrial fatty acid oxidation should be considered in infants with conduction defects or ventricular tachycardia.

  • Among those, the amino terminus of NIP6;1 has some characteristics of a mitochondrial signal peptide sequence - a series of positive charges separated by two to four amino acids.


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