Words similar to lck
Example sentences for: lck
How can you use “lck” in a sentence? Here are some example sentences to help you improve your vocabulary:
Consistent with SH-2 interaction, CD5 cytoplasmic tyrosine residues are phosphorylated by p56 lck kinases upon TCR/CD3 ligation and serve as targets for association with proteins containing SH2 domains in both T and B-1a cells [ 12, 21, 22].
Specific CD98-integrin interaction occurs in the context of low density protein-lipid microdomains, possibly resembling lipid rafts [ 34 35 ] . Several important signaling molecules, including activated TCR, LAT and LCK are present in organized raft-type microdomains, and integrity of these microdomains is necessary for T cell receptor signal transduction [ 36 37 ] . Our present discovery that β1 integrins specifically associate with CD98 in lipid microdomains helps to explain the functional connections between β1 integrins and CD98 during T cell costimulation, monocyte fusion, and elsewhere.
Although our original SH3 domain binding experiments suggested a specific interaction between Tec kinases and the Src kinases Fyn, Lyn and Hck, we have been able to observe both activation by and co-precipitation with other Src family kinases including Lck and Src in 293T cells (data not shown).
Indeed, we have found that mutation of the proline-rich region did not abolish Rlk co-precipitation with either Fyn or Lck (data not shown), suggesting that interactions between these kinases may not occur solely through an SH3 mediated interaction, at least in the 293T expression system.
GST fusions encoding the Rlk amino-terminal and SH3 domains or the amino-terminus alone (containing the cysteine string and proline-rich region) bound biotinylated GST fusions of the SH3 domains of Fyn, Hck, and Lyn, but not those of Src or Lck, despite the ability of these constructs to bind other proline rich sequences (Fig.
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