Words similar to lcd
Example sentences for: lcd
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In budding yeast, LCD1 Rad26physically interacts with MEC1 Rad3and is phosphorylated by MEC1 Rad3following DNA damage [ 36 37 ] . Likewise, human ATRIP Rad26physically interacts with ATR Rad3and also undergoes DNA damage-dependent phosphorylation by ATR Rad3 [ 35 ] . However, Rad26 is required for Rad3 kinase activity in fission yeast [ 18 ] , but LCD1 Rad26is not required for MEC1 Rad3kinase activity [ 38 ] while ATRIP Rad26is required for normal ATR Rad3expression [ 35 ] . Thus, the role of the Rad26-related proteins can differ among organisms.
Rad26 is a regulatory subunit of the Rad26/Rad3 complex that is required for Rad3 kinase activity [ 18 ] . Following DNA damage, Rad26 undergoes Rad3-dependent phosphorylation [ 17 ] . Rad26 is a 70 kDa protein containing little informative sequence information beyond a predicted coiled-coil region and a basic stretch that resembles a nuclear localization signal [ 13 32 ] . Functionally conserved proteins with very weak sequence similarity have been found in human (ATRIP) [ 35 ] , S. cerevisiae LCD1 (aka DDC2 and PIE1) [ 36 37 38 ] and A. nidulans (UVSD) [ 32 ] .
Unlike ATRIP and LCD1-GFP, Rad26-GFP also localizes to one or two bright spots following DNA damage (Figure 5).
DNA repair activities may take place at these foci since BRCA1 has been shown to co-localize with ATR in damage-induced foci [ 58 ] . Using elegant methods to test for direct association of DNA damage checkpoint proteins at double strand breaks in vivo , other groups have shown that MEC1 Rad3-HA and LCD1 Rad26-GFP localize to sites of DNA damage [ 59 60 ] . However, MEC1 was required for this re-localization of LCD1-GFP in vivo [ 60 ] . Thus, while re-localization of Rad26/Rad3-related complexes to sites of DNA repair may be evolutionarily conserved, the regulation of these complexes is not.
) Entrenched equipment manufacturer Rawlings is set to respond with such products as a baseball containing a microchip that enables it to calculate the speed at which it's thrown, a datum displayed on an LCD on the baseball's skin.
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