Words similar to kcnq
Example sentences for: kcnq
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Like the Kv3 ( Shaw ) family, KQT (KCNQ) K +-channel genes are more abundant in Anopheles than in Drosophila . Sequence analysis suggests these channels evolved before other classical voltage-gated K +channels (Kv1-K4).
Of these two control elements, the closest to Tnfrh1 is KvDMR1, located in an intron of the Kcnq1 gene and giving rise to the Kcnq1ot1 non-translated RNA.
Voltage-gated K +currents with distinct electrophysiological and pharmacological properties are present in granulosa cells (GC), and modulate resting membrane potential [ 4 12 13 16 17 ] . Furthermore, selective antagonism of GC K +channels with distinct molecular correlates, electrophysiological properties and expression patterns can influence differentially GC proliferation, steroidogenic capability, and apoptosis [ 17 18 ] . Our laboratory has previously identified two distinct delayed rectifier K +currents in pig GC: a slow current (I Ks ) associated with channels formed by co-assembly of KCNQ1 pore-forming and KCNE1 accessory proteins, and an ultra-rapid current (I Kur ) formed by co-assembly of KCNA pore-forming and KCNAB accessory proteins [ 4 ] . Moreover, we have shown that selective block of I Ks enhances basal progesterone synthesis, while complete block of both I Ks and I Kur accelerates apoptosis [ 18 ] .
This element, which is ~350 kb distant from Tnfrh1 , is essential in cis for the imprinting of at least 4 genes, Kcnq1 , Cdkn1c , Slc22a1l and Ipl/Tssc3 ( [ 21 22 23 ] and M. Higgins, personal communication).
Drosophila , KCNQ, which raises questions about whether products of this gene mediate the M-current, as has been postulated for KCNQ2 and KCNQ3 in mammals [ 28 ] .
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