Words similar to kcnq
Example sentences for: kcnq
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Drosophila , KCNQ, which raises questions about whether products of this gene mediate the M-current, as has been postulated for KCNQ2 and KCNQ3 in mammals [ 28 ] .
These two elements control, respectively, the allele-specific expression of the H19/Igf2/Ins2 gene cluster, and the second gene cluster containing Kcnq1, the antisense transcript Kcnq1ot1, p57 Kip 2/ Cdkn1c, Slc22a1l, Ipl/Tssc3 and possibly additional genes [ 1 2 ] . There is good evidence assigning one border of the overall imprinted region to the DNA immediately downstream of H19 [ 3 ] . However, the other border, which must lie upstream of Ipl is less well-defined [ 4 ] . Here we show evidence for weak imprinting of a gene, Tnfrh1 , which is located upstream of
These correspond to short differentially methylated DNA sequences (DMRs) - one immediately upstream of the H19 gene and another within an intron of the Kcnq1 gene.
Voltage-gated K +currents with distinct electrophysiological and pharmacological properties are present in granulosa cells (GC), and modulate resting membrane potential [ 4 12 13 16 17 ] . Furthermore, selective antagonism of GC K +channels with distinct molecular correlates, electrophysiological properties and expression patterns can influence differentially GC proliferation, steroidogenic capability, and apoptosis [ 17 18 ] . Our laboratory has previously identified two distinct delayed rectifier K +currents in pig GC: a slow current (I Ks ) associated with channels formed by co-assembly of KCNQ1 pore-forming and KCNE1 accessory proteins, and an ultra-rapid current (I Kur ) formed by co-assembly of KCNA pore-forming and KCNAB accessory proteins [ 4 ] . Moreover, we have shown that selective block of I Ks enhances basal progesterone synthesis, while complete block of both I Ks and I Kur accelerates apoptosis [ 18 ] .
The neighbor-joining (Figure 3a) and maximum-likelihood trees we constructed, in combination with the fact that mammalian KCNQ1 and Anopheles KCNQ2 gene products share a striking 75% identity (despite the divergence of protostomes and deuterostomes close to 700 million years ago), suggest that gene loss in Drosophila , specifically loss of an ancestral KCNQ2 (mammalian KCNQ1 ), is the cause of this difference, rather than gene expansion in Anopheles , which may be the case for the Kv3 and Irk3 (Figure 3b) gene families.
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