Words similar to kcnq
Example sentences for: kcnq
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This element, which is ~350 kb distant from Tnfrh1 , is essential in cis for the imprinting of at least 4 genes, Kcnq1 , Cdkn1c , Slc22a1l and Ipl/Tssc3 ( [ 21 22 23 ] and M. Higgins, personal communication).
Voltage-gated K +currents with distinct electrophysiological and pharmacological properties are present in granulosa cells (GC), and modulate resting membrane potential [ 4 12 13 16 17 ] . Furthermore, selective antagonism of GC K +channels with distinct molecular correlates, electrophysiological properties and expression patterns can influence differentially GC proliferation, steroidogenic capability, and apoptosis [ 17 18 ] . Our laboratory has previously identified two distinct delayed rectifier K +currents in pig GC: a slow current (I Ks ) associated with channels formed by co-assembly of KCNQ1 pore-forming and KCNE1 accessory proteins, and an ultra-rapid current (I Kur ) formed by co-assembly of KCNA pore-forming and KCNAB accessory proteins [ 4 ] . Moreover, we have shown that selective block of I Ks enhances basal progesterone synthesis, while complete block of both I Ks and I Kur accelerates apoptosis [ 18 ] .
Alternatively, lateral transfer of KCNQ1 from mammals to Anopheles must be considered, given the intimate relationship of these organisms.
KCNQ family proteins.
The neighbor-joining (Figure 3a) and maximum-likelihood trees we constructed, in combination with the fact that mammalian KCNQ1 and Anopheles KCNQ2 gene products share a striking 75% identity (despite the divergence of protostomes and deuterostomes close to 700 million years ago), suggest that gene loss in Drosophila , specifically loss of an ancestral KCNQ2 (mammalian KCNQ1 ), is the cause of this difference, rather than gene expansion in Anopheles , which may be the case for the Kv3 and Irk3 (Figure 3b) gene families.
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