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Example sentences for: kcf

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In addition, the synthetic forms of KcC7, KcD11, KcF6 and the recombinant KcF12 (rKcF12) were able to compete the binding of TNFα and TNFβ, as well as KcF6 and KcF12 phage clones in the micromolar range (unpublished data).
The peptides were initially divided into two groups: a 40 mer designated KcF12 and three 20 mers designated KcC7, KcD11 and KcF6 (Table 1).
It has been previously reported that TNFα induced a TNFR2-specific proliferation of the neuroblastoma cell line SK-N-BE [ 30 ] . KcF12, KcC7 and KcF6 inhibited the proliferative response to TNF-α in this cell line indicating that they could act as antagonists (data not shown).
KcF12 inhibits TNFα binding to Jiyoye cells with a Ki of about 2 uM whereas the Ki for the peptide in Jurkat cells was found to be >30 uM (Figure 3).
This is surprising because these peptides share a hotspot with the natural ligand TNFα (which is proliferative rather than-cytotoxic) and KcC7 and KcF6 bind to a hotspot common to the neutralizing but non-cytotoxic, antibody mAb226.