Example sentences for: kcc

How can you use “kcc” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • While all of the peptides blocked the agonist effects of TNFα indicating that they can act as antagonists, KcC7, KcF6 and KcF12 by themselves induced a cytotoxic response by killing SK-N-BE cells in the absence of TNFα.

  • From the amino acid sequences, KcC7, KcD11 and KcF12 were found to have a pair of cysteine residues suggesting the possibility of intra-chain disulfide bonding.

  • It has been previously reported that TNFα induced a TNFR2-specific proliferation of the neuroblastoma cell line SK-N-BE [ 30 ] . KcF12, KcC7 and KcF6 inhibited the proliferative response to TNF-α in this cell line indicating that they could act as antagonists (data not shown).

  • This is surprising because these peptides share a hotspot with the natural ligand TNFα (which is proliferative rather than-cytotoxic) and KcC7 and KcF6 bind to a hotspot common to the neutralizing but non-cytotoxic, antibody mAb226.

  • Competition experiments showing that mAb 226 reversed the effects of KcC7 and KcF6 confirm that these two peptides induce their effects though their interaction with TNFR2.


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