Words similar to kcsa

Example sentences for: kcsa

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Homology models [ 3 4 ] of the M1-P-M2 portion of Kir's have been developed using the backbone structure of KcsA.
Finally, in our hands homology models based on KcsA developed with Alignment A satisfy the mutagenesis data on which Alignment B is based as do models using alignment B, and models using Alignment A are more consistent with mutagenesis studies of other groups [ 3 13 ] . No single model in which the P segment has the structure of KcsA can satisfy all of the second site suppressor data of Minor et al.
The validity of these models has been challenged by experiments [ 5 ] that were interpreted as indicating that the sequence alignment between KcsA and Kir proposed originally by Doyle et al [ 2 ] for M2 and used in these models is incorrect.
The structural interactions that underlie tetramerization of KcsA on gels are disrupted only by heating the sample and by pH 12 [ 31 ] , treatments that had no effect on the dimerization of VR1 we observed (data not shown).
The bacterial K +channel KcsA, whose X-ray crystal structure has been solved and is definitively a tetramer [ 30 ] , runs as a tetramer on SDS gels [ 31 ] . Furthermore, mutations that disrupt a known intersubunit interface at the level of the pore disrupt this biochemical tetramerization.