Example sentences for: kcsa
How can you use “kcsa” in a sentence? Here are some example sentences to help you improve your vocabulary:
Finally, in our hands homology models based on KcsA developed with Alignment A satisfy the mutagenesis data on which Alignment B is based as do models using alignment B, and models using Alignment A are more consistent with mutagenesis studies of other groups [ 3 13 ] . No single model in which the P segment has the structure of KcsA can satisfy all of the second site suppressor data of Minor et al.
The validity of these models has been challenged by experiments [ 5 ] that were interpreted as indicating that the sequence alignment between KcsA and Kir proposed originally by Doyle et al [ 2 ] for M2 and used in these models is incorrect.
[ 5 ] . However, their data are from an open conformation and the KcsA structure is probably a closed conformation.
The bacterial K +channel KcsA, whose X-ray crystal structure has been solved and is definitively a tetramer [ 30 ] , runs as a tetramer on SDS gels [ 31 ] . Furthermore, mutations that disrupt a known intersubunit interface at the level of the pore disrupt this biochemical tetramerization.
1 has a structure different from that of KcsA in which M1 interacts with M1 helices of adjacent subunits throughout the entire transmembrane region.