Example sentences for: kcsa
How can you use “kcsa” in a sentence? Here are some example sentences to help you improve your vocabulary:
Finally, in our hands homology models based on KcsA developed with Alignment A satisfy the mutagenesis data on which Alignment B is based as do models using alignment B, and models using Alignment A are more consistent with mutagenesis studies of other groups [ 3 13 ] . No single model in which the P segment has the structure of KcsA can satisfy all of the second site suppressor data of Minor et al.
The bacterial K +channel KcsA, whose X-ray crystal structure has been solved and is definitively a tetramer [ 30 ] , runs as a tetramer on SDS gels [ 31 ] . Furthermore, mutations that disrupt a known intersubunit interface at the level of the pore disrupt this biochemical tetramerization.
It is highly unlikely that the only portion of the protein with substantial sequence identity between Kir's and KcsA and that determines the selectivity of the channels for potassium would have entirely different structures and/or exist in different locations in these two proteins.
Three groups [ 2 3 4 ] have used Alignment A for M2 of KcsA and the eukaryotic Kir's.
We also aligned the M1-P-M2 region of KcsA with the ten bacterial sequences in the microbial sequence database that were most similar to KcsA to produce a KcsA-like family.
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