Words similar to ifng-mediated

Example sentences for: ifng-mediated

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Previously, PMA was shown to augment IFNg-mediated MHCII expression in MHCII-inducible tumor cell lines [ 19 20 ] . Here, we report that the presence of PMA in tissue culture restores IFNg-dependent MHCII expression in the poorly-responding LS1034 colon carcinoma cell line but fails to produce this effect in two other IFNg-resistant cell lines, MSTO-211H mesothelioma and HepG2 hepatocellular carcinoma.
A substantial percentage of human tumors lose the expression of the retinoblastoma tumor suppressor protein (Rb), important as a necessary condition for IFNg-mediated induction of MHCII [ 21 ] . Therefore, we wished to determine whether the poor IFNg inducibility of MHCII in LS1034, MSTO-211H and HepG2 cell lines could be explained by the loss of Rb.